SAP97 Antibody – Rabbit Polyclonal

Synapse-associated protein (SAP) 97 is a 97 kD membrane-associated synapse protein with extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1). SAP97 consists of three 90 amino acid PDZ domains at its amino terminus, followed by a Src homology (SH) 3 domain, and a region with homology to guanylate kinases (GK). In addition to the CNS, SAP97 is also detected at the basal lateral membrane between a variety of epithelial cells. SAP97 is recruited to the submembranous cortical cytoskeleton at cell-cell contact sites as part of the E-cadherin complex. Co-expression of SAP97 and K+ channel results in the colocalization of these proteins in large round intracellular aggregates. SAP 97 has been shown to have functional homology to Drosophila tumor suppressor protein (DlgA), a PSD 95 related protein involved in maintaining integrity of epithelial and neuromuscular junctions.

Small volumes of anti-SAP97 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS614487 is an antibody targeting SAP97. Also known as SAP97 (Synapse-associated Protein 97, Discs Large Homolog 1, DLG1, dJ1061C18.1.1, DKFZp761P0818, DLGH1, HDLG, Presynaptic Protein SAP97). Reactive in Mouse, Rat. Host: Rabbit.