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Dihydropyrimidine Dehydrogenase (DPD) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6146845

MBS6146845 is an antibody targeting DPD. Also known as Dihydropyrimidine Dehydrogenase (DPD, DPYD, DHP, DHPDHase, Dihydrothymine Dehydrogenase, Dihydrouracil Dehydrogenase, MGC70799, MGC132008) (FITC). Reactive in Human. Host: Mouse. More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Dihydropyrimidine Dehydrogenase (DPD), Monoclonal Antibody
Full Product Name
Dihydropyrimidine Dehydrogenase (DPD, DPYD, DHP, DHPDHase, Dihydrothymine Dehydrogenase, Dihydrouracil Dehydrogenase, MGC70799, MGC132008) (FITC)
Product Gene Name
anti-DPD antibody
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
7D4
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human DPYD.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
18,936 Da
OMIM
274270
3D Structure
ModBase 3D Structure for Q12882
Immunogen
Partial recombinant corresponding to aa1-110 from human DPYD (NP_000101) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYY
Conjugate
FITC

Product Categories/Family for anti-DPD antibody

Antibodies; Enzymes; Dehydrogenase
Applications Tested/Suitable for anti-DPD antibody
ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-DPD antibody
IF: 10ug/ml
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DPD antibody

Western Blot detection against Immunogen (37.84kD).
Mouse Anti-DPD Monoclonal Antibody – Cat# MBS6146845

Western Blot (WB) of anti-DPD antibody

DPYD monoclonal antibody, Western Blot analysis of DPYD expression in HeLa.
Mouse Anti-DPD Monoclonal Antibody, Western Blot (WB) – Cat# MBS6146845

Western Blot (WB) of anti-DPD antibody

DPYD monoclonal antibody. Western Blot analysis of DPYD expression in Hela NE.
Mouse Anti-DPD Monoclonal Antibody, Western Blot (WB) – Cat# MBS6146845

Immunofluorescence (IF) of anti-DPD antibody

Immunofluorescence of monoclonal antibody to DPYD on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-DPD Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS6146845

Testing Data of anti-DPD antibody

Detection limit for recombinant GST tagged DPYD is ~0.1ng/ml as a capture antibody.
Mouse Anti-DPD Monoclonal Antibody, Testing Data – Cat# MBS6146845

Other Notes

Small volumes of anti-DPD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DPD. It may not necessarily be applicable to this product.

NCBI GI #
119943098
NCBI GeneID
1806
NCBI Accession #
NP_000101
UniProt Primary Accession #
Q12882
UniProt Secondary Accession #
Q16694; Q16761; Q32NB0; Q96HL6; Q96TH1; A2RRQ2; A2RRQ3; A8K5A2; A8MWG9; B1AN21; E9PFN1
UniProt Related Accession #
Q12882
GenBank Nucleotide #
NM_000110
NCBI Official Full Name
dihydropyrimidine dehydrogenase
NCBI Official Synonym Full Names
dihydropyrimidine dehydrogenase
NCBI Official Symbol
DPYD
NCBI Official Synonym Symbols
DHP; DPD; DHPDHASE
UniProt Protein Name
Dihydropyrimidine dehydrogenase [NADP(+)]
UniProt Synonym Protein Names
Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase
Protein Family
Dihydropyrimidine dehydrogenase
UniProt Gene Name
DPYD
UniProt Synonym Gene Names
DHPDHase; DPD
UniProt Entry Name
DPYD_HUMAN
NCBI Protein Information
dihydropyrimidine dehydrogenase [NADP(+)]; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase

UniProt Comments for DPD

DPYD: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Homodimer. Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. Belongs to the dihydropyrimidine dehydrogenase family.

Protein type: Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; EC 1.3.1.2; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: cytoplasm; cytosol

Molecular Function: protein homodimerization activity; FAD binding; metal ion binding; dihydroorotate dehydrogenase activity; 4 iron, 4 sulfur cluster binding; dihydropyrimidine dehydrogenase (NADP+) activity; NADP binding

Biological Process: pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; UMP biosynthetic process; uracil catabolic process; thymine catabolic process; beta-alanine biosynthetic process; purine base catabolic process; pyrimidine base catabolic process; thymidine catabolic process

Disease: Dihydropyrimidine Dehydrogenase Deficiency
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DPD antibody

 Reference Product  PubMed Publications
 TYMP antibody  >8 publications with DPD and TYMP
 CYP2A6 antibody  >3 publications with DPD and CYP2A6
 UPB1 antibody  >2 publications with DPD and UPB1
 DPYS antibody  >2 publications with DPD and DPYS
 UPP1 antibody  >1 publications with DPD and UPP1
 UMPS antibody  >1 publications with DPD and UMPS

Pathways associated with anti-DPD antibody

 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pyrimidine Catabolism Pathway antibodies  Pyrimidine Catabolism Pathway Diagram
 Pyrimidine Degradation, Uracil => Beta-alanine, Thymine => 3-aminoisobutanoate Pathway antibodies  Pyrimidine Degradation, Uracil => Beta-alanine, Thymine => 3-aminoisobutanoate Pathway Diagram

Diseases associated with anti-DPD antibody

 Disease Name  Pubmed Publications
 Dihydropyrimidine Dehydrogenase Deficiency Antibodies  >74 publications with DPD and Dihydropyrimidine Dehydrogenase Deficiency
 Gastrointestinal Diseases Antibodies  >66 publications with DPD and Gastrointestinal Diseases
 Gastrointestinal Neoplasms Antibodies  >65 publications with DPD and Gastrointestinal Neoplasms
 Colorectal Neoplasms Antibodies  >56 publications with DPD and Colorectal Neoplasms
 Carcinoma Antibodies  >36 publications with DPD and Carcinoma
 Purine-Pyrimidine Metabolism, Inborn Errors Antibodies  >36 publications with DPD and Purine-Pyrimidine Metabolism, Inborn Errors
 Breast Neoplasms Antibodies  >21 publications with DPD and Breast Neoplasms
 Diarrhea Antibodies  >21 publications with DPD and Diarrhea
 Adenocarcinoma Antibodies  >19 publications with DPD and Adenocarcinoma
 Neutropenia Antibodies  >18 publications with DPD and Neutropenia

Organs/Tissues associated with anti-DPD antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >65 publications with DPD and Blood
 Bone Antibodies  >30 publications with DPD and Bone
 Liver Antibodies  >16 publications with DPD and Liver
 Connective Tissue Antibodies  >10 publications with DPD and Connective Tissue
 Lung Antibodies  >8 publications with DPD and Lung
 Prostate Antibodies  >6 publications with DPD and Prostate
 Skin Antibodies  >5 publications with DPD and Skin
 Brain Antibodies  >5 publications with DPD and Brain
 Kidney Antibodies  >4 publications with DPD and Kidney
 Nerve Antibodies  >4 publications with DPD and Nerve
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