Smad Ubiquitination Regulatory Factor-1 (SMURF1) Antibody – Rabbit Polyclonal

Smurf1 (Smad ubiquitination regulatory factor-1) is a member of the Hect family of proteins, which also includes the ubiquitin (Ub) E3-type ligases Nedd3 and E6-AP. E3 ligases are involved in the enzymatic reactions of the Ub conjugating pathway that targets proteins for degradation by the 26S proteasome. In the Ub pathway, E3 ligases catalyze the transfer of Ub from Ub-conjugating enzymes to the individual protein substrate. As an E3 ligase, Smurf1 preferentially promotes the transfer of Ub to Smad proteins, thereby targeting them for degradation. Smurf1 regulates the inhibitory activity of Smad by targeting it to the plasma membrane, and is also known to enhance the degradation of the inhibitory Smad1 and Smad5, thereby down-regulating the BMP pathway, which controls embryomic development and the specification of ectoderm- and mesoderm-derived tissues.

Small volumes of anti-SMURF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS614685 is an antibody targeting SMURF1. Also known as Smad Ubiquitination Regulatory Factor-1 (Smurf1). Reactive in Human, Mouse. Host: Rabbit.