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DSC2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6146915

MBS6146915 is an antibody targeting DSC2. Also known as DSC2 (Desmocollin-2, Cadherin Family Member 2, Desmocollin-3, Desmosomal Glycoprotein II, Desmosomal Glycoprotein III, CDHF2, DSC3) (FITC). Reactive in Human. Host: Mouse. More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DSC2, Monoclonal Antibody
Full Product Name
DSC2 (Desmocollin-2, Cadherin Family Member 2, Desmocollin-3, Desmosomal Glycoprotein II, Desmosomal Glycoprotein III, CDHF2, DSC3) (FITC)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
4D2
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human DSC3.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
85kDa
OMIM
600271
3D Structure
ModBase 3D Structure for Q14574
Immunogen
Partial recombinant corresponding to aa585-684 from human DSC3 (NP_001932) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
CKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRST
Conjugate
FITC

Product Categories/Family for anti-DSC2 antibody

Applications Tested/Suitable for anti-DSC2 antibody
ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-DSC2 antibody
IF: 10ug/ml
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DSC2 antibody

Western Blot detection against Immunogen (36.74kD).
Mouse Anti-DSC2 Monoclonal Antibody – Cat# MBS6146915

Immunofluorescence (IF) of anti-DSC2 antibody

Immunofluorescence of monoclonal antibody to DSC3 on A-431 cell. [antibody concentration 10ug/ml].
Mouse Anti-DSC2 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS6146915

Testing Data of anti-DSC2 antibody

Detection limit for recombinant GST tagged DSC3 is ~1ng/ml as a capture antibody.
Mouse Anti-DSC2 Monoclonal Antibody, Testing Data – Cat# MBS6146915

Other Notes

Small volumes of anti-DSC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DSC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
desmocollin-3 isoform Dsc3a preproprotein
NCBI Official Synonym Full Names
desmocollin 3
NCBI Official Symbol
DSC3
NCBI Official Synonym Symbols
DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP
UniProt Protein Name
Desmocollin-3
UniProt Synonym Protein Names
Cadherin family member 3; Desmocollin-4; HT-CP
Protein Family
UniProt Gene Name
DSC3
UniProt Synonym Gene Names
CDHF3; DSC4
UniProt Entry Name
DSC3_HUMAN
NCBI Protein Information
desmocollin-3

NCBI Summary for DSC2

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DSC2 antibody

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