Rabbit Anti-POLI Polyclonal Antibody – Cat# MBS614888

DNA Polymerase, Iota (POLI) Antibody – Rabbit Polyclonal

Name: POLI Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS614888
Price: 595 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS614888

DNA polymerase Iota (pol iota, also known as Rad30B) is a novel human polymerase, unlike any others known. It is an extremely low-fidelity enzyme that is highly error-prone when replicating undamaged and damaged DNA in vitro. To date there is, however, no… More details

$595 / 0.05 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DNA Polymerase, iota (POLI), Polyclonal Antibody

Full Product Name

DNA Polymerase, iota

Product Gene Name

anti-POLI antibody

Product Synonym Names

Anti -DNA Polymerase, iota

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.

Purity/Purification

Serum
Serum

Specificity

Specific for human DNA Polymerase Iota

Preparation and Storage

-20 degree C

Molecular Weight

83,006 Da

Chromosome Location

Chromosome: 18; NC_000018.9 (51795849..51824604). Location: 18q21.1

OMIM

605252

3D Structure

ModBase 3D Structure for Q9UNA4

Immunogen

A 15-mer peptide in the C-terminal region of human DNA Polymerase Iota, conjugated to KLH.

Positive Control

HeLa whole cell extract (100ug) or GM0193 (lymphoblastoid cell line).

Product Categories/Family for anti-POLI antibody

Antibodies; Abs to Enzymes; Polymerase

Applications Tested/Suitable for anti-POLI antibody

Western Blot (WB)

Other Notes

Small volumes of anti-POLI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POLI purchase

MBS614888 is an antibody targeting POLI. Also known as DNA Polymerase, iota. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for POLI. It may not necessarily be applicable to this product.

NCBI GI #

154350220

NCBI GeneID

11201

NCBI Accession #

NP_009126.2

UniProt Primary Accession #

Q9UNA4

UniProt Secondary Accession #

Q8N590; Q9H0S1; Q9NYH6

UniProt Related Accession #

Q9UNA4

GenBank Nucleotide #

NM_007195.2

NCBI Official Full Name

DNA polymerase iota

NCBI Official Synonym Full Names

polymerase (DNA directed) iota

NCBI Official Symbol

POLI

NCBI Official Synonym Symbols

RAD30B; RAD3OB

UniProt Protein Name

DNA polymerase iota

UniProt Synonym Protein Names

Eta2; RAD30 homolog B

Protein Family

DNA polymerase

UniProt Gene Name

POLI

UniProt Synonym Gene Names

RAD30B

UniProt Entry Name

POLI_HUMAN

NCBI Protein Information

DNA polymerase iota; eta2; RAD30 homolog B; OTTHUMP00000163557; polymerase (DNA-directed), iota

UniProt Comments for POLI

POLI: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. Belongs to the DNA polymerase type-Y family.

Protein type: DNA repair, damage; EC 2.7.7.7; Transferase

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; intracellular; nucleus

Molecular Function: protein binding; metal ion binding; damaged DNA binding; DNA-directed DNA polymerase activity

Biological Process: DNA replication; DNA repair

Research Articles on POLI

1. structural mechanism of high-fidelity 8-oxo-G replication by a human DNA polymerase

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-POLI antibody

Reference Product	PubMed Publications
POLH antibody	>8 publications with POLI and POLH
PCNA antibody	>2 publications with POLI and PCNA
REV1 antibody	>2 publications with POLI and REV1

Pathways associated with anti-POLI antibody

Products by Pathway	Pathway Diagram
Fanconi Anemia Pathway antibodies	Fanconi Anemia Pathway Diagram
Fanconi Anemia Pathway antibodies	Fanconi Anemia Pathway Diagram

Diseases associated with anti-POLI antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>245 publications with POLI and Neoplasms
Liver Diseases Antibodies	>123 publications with POLI and Liver Diseases
Skin Diseases Antibodies	>103 publications with POLI and Skin Diseases
Lung Diseases Antibodies	>103 publications with POLI and Lung Diseases
Myocardial Infarction Antibodies	>63 publications with POLI and Myocardial Infarction
Kidney Diseases Antibodies	>63 publications with POLI and Kidney Diseases
Stroke Antibodies	>49 publications with POLI and Stroke
Pain Antibodies	>47 publications with POLI and Pain
Neurodegenerative Diseases Antibodies	>31 publications with POLI and Neurodegenerative Diseases
Heart Failure Antibodies	>30 publications with POLI and Heart Failure

Organs/Tissues associated with anti-POLI antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>718 publications with POLI and Blood
Liver Antibodies	>261 publications with POLI and Liver
Heart Antibodies	>178 publications with POLI and Heart
Kidney Antibodies	>161 publications with POLI and Kidney
Brain Antibodies	>152 publications with POLI and Brain
Muscle Antibodies	>120 publications with POLI and Muscle
Bone Antibodies	>88 publications with POLI and Bone
Lung Antibodies	>75 publications with POLI and Lung
Skin Antibodies	>69 publications with POLI and Skin
Intestine Antibodies	>56 publications with POLI and Intestine