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Tankyrase (TNKS) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6151005

MBS6151005 is an antibody targeting TNKS. Also known as Tankyrase (TRF1-interacting Ankyrin-related ADP-ribose Polymerase, TNKS, Tankyrase I, Tankyrase-I, TANK1, TNKS1, TNKS-1, PARP-5a, PARP5a, PARPL, TIN1, TINF1) (Azide Free) (HRP). Reactive in Human. Host:… More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Tankyrase (TNKS), Monoclonal Antibody
Full Product Name
Tankyrase (TRF1-interacting Ankyrin-related ADP-ribose Polymerase, TNKS, Tankyrase I, Tankyrase-I, TANK1, TNKS1, TNKS-1, PARP-5a, PARP5a, PARPL, TIN1, TINF1) (Azide Free) (HRP)
Product Gene Name
anti-TNKS antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
11C843
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Purity/Purification
Purified from ascites by protein A affinity chromatography.
Specificity
Recognizes human TNKS.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
67,203 Da
OMIM
603303
3D Structure
ModBase 3D Structure for O95271
Immunogen
Partial recombinant protein corresponding to a region near a portion of amino acids within aa1017-1125 of human TNKS with a GST tag. (NP_003738)
Conjugate
HRP

Product Categories/Family for anti-TNKS antibody

Antibodies; Enzymes; Polymerase
Applications Tested/Suitable for anti-TNKS antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-TNKS antibody
ELISA: 1ug/ml-3ng/ml
WB: 1:500-1:1,000
Applications are based on unconjugated antibody.

Immunohistochemistry (IHC) of anti-TNKS antibody

Staining of paraffin embedded human lymph node with T0900-20B.
Mouse Anti-TNKS Monoclonal Antibody – Cat# MBS6151005

Testing Data of anti-TNKS antibody

Detection limit for recombinant GST tagged TNKS is approximately 0.1ng/ml as a capture antibody.
Mouse Anti-TNKS Monoclonal Antibody, Testing Data – Cat# MBS6151005

Other Notes

Small volumes of anti-TNKS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNKS. It may not necessarily be applicable to this product.

NCBI GI #
87239981
NCBI GeneID
8658
NCBI Accession #
NP_003738
UniProt Primary Accession #
O95271
UniProt Secondary Accession #
O95272; Q4G0F2
UniProt Related Accession #
O95271
GenBank Nucleotide #
NM_003747
NCBI Official Full Name
tankyrase-1
NCBI Official Synonym Full Names
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
NCBI Official Symbol
TNKS
NCBI Official Synonym Symbols
TIN1; ARTD5; PARPL; TINF1; TNKS1; pART5; PARP5A; PARP-5a
UniProt Protein Name
Tankyrase-1
UniProt Synonym Protein Names
ADP-ribosyltransferase diphtheria toxin-like 5; ARTD5; Poly [ADP-ribose] polymerase 5A; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; Tankyrase I
Protein Family
Tankyrase
UniProt Gene Name
TNKS
UniProt Synonym Gene Names
PARP5A; PARPL; TIN1; TINF1; TNKS1; TANK1; ARTD5
UniProt Entry Name
TNKS1_HUMAN
NCBI Protein Information
tankyrase-1; ADP-ribosyltransferase diphtheria toxin-like 5; TANK1; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; poly [ADP-ribose] polymerase 5A; tankyrase I

UniProt Comments for TNKS

TNKS: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.2.30; Transferase

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: Golgi membrane; spindle pole; Golgi apparatus; pericentriolar material; chromosome, telomeric region; nuclear membrane; nuclear chromosome, telomeric region; nuclear pore; cytosol; chromosome, pericentric region

Molecular Function: protein binding; zinc ion binding; NAD+ ADP-ribosyltransferase activity

Biological Process: mitosis; protein polyubiquitination; mRNA transport; Wnt receptor signaling pathway; peptidyl-threonine phosphorylation; spindle assembly; negative regulation of DNA binding; positive regulation of telomere maintenance via telomerase; peptidyl-serine phosphorylation; protein amino acid ADP-ribosylation; protein transport; mitotic spindle organization and biogenesis; cell division; positive regulation of transcription from RNA polymerase II promoter; regulation of telomere maintenance via telomerase
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNKS antibody

 Reference Product  PubMed Publications
 TNKS2 antibody  >11 publications with TNKS and TNKS2
 POT1 antibody  >9 publications with TNKS and POT1
 TERF1 antibody  >4 publications with TNKS and TERF1
 NUMA1 antibody  >4 publications with TNKS and NUMA1
 TNKS1BP1 antibody  >2 publications with TNKS and TNKS1BP1

Pathways associated with anti-TNKS antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
 Degradation Of AXIN Pathway antibodies  Degradation Of AXIN Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram

Diseases associated with anti-TNKS antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with TNKS and Neoplasms
 Breast Neoplasms Antibodies  >6 publications with TNKS and Breast Neoplasms
 Genetic Diseases, Inborn Antibodies  >3 publications with TNKS and Genetic Diseases, Inborn
 Lymphoma Antibodies  >2 publications with TNKS and Lymphoma
 Genital Diseases, Male Antibodies  >1 publications with TNKS and Genital Diseases, Male

Organs/Tissues associated with anti-TNKS antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with TNKS and Blood
 Muscle Antibodies  >6 publications with TNKS and Muscle
 Brain Antibodies  >5 publications with TNKS and Brain
 Kidney Antibodies  >4 publications with TNKS and Kidney
 Bone Marrow Antibodies  >4 publications with TNKS and Bone Marrow
 Bone Antibodies  >4 publications with TNKS and Bone
 Lymph Antibodies  >2 publications with TNKS and Lymph
 Lung Antibodies  >2 publications with TNKS and Lung
 Lymph Node Antibodies  >2 publications with TNKS and Lymph Node
 Embryonic Tissue Antibodies  >2 publications with TNKS and Embryonic Tissue
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