ATP6V1E1 Antibody – Mouse Monoclonal

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008]

ATP6V0E1: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase e1/e2 subunit family.

Protein type: Transporter, ion channel; Membrane protein, integral; Transporter, iron; Transporter; Hydrolase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: phagocytic vesicle membrane; membrane; integral to membrane; endosome membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of ions; transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism

Biological Process: interaction with host; vacuolar acidification; proton transport; cellular iron ion homeostasis; metabolic process; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; response to amino acid stimulus; cell growth; transmembrane transport