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CNR2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6151882

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNR2, Monoclonal Antibody
Full Product Name
CNR2 (Cannabinoid Receptor 2, CB-2, CB2, hCB2, CX5) (HRP)
Product Gene Name
anti-CNR2 antibody
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
3C7
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human CNR2.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
39,681 Da
OMIM
605051
3D Structure
ModBase 3D Structure for P34972
Immunogen
Partial recombinant protein corresponding to aa302-360 from human CNR2 (NP_001832.1) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
RSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
Conjugate
HRP

Product Categories/Family for anti-CNR2 antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-CNR2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CNR2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CNR2 antibody

Western Blot detection against immunogen (32.12kD).
Mouse Anti-CNR2 Monoclonal Antibody – Cat# MBS6151882

Western Blot (WB) of anti-CNR2 antibody

Western Blot analysis of CNR2 expression in transfected 293T cell line by 125147. Lane 1: CNR2 transfected lysate (39.7kD). Lane 2: Non-transfected lysate.
Mouse Anti-CNR2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6151882

Testing Data of anti-CNR2 antibody

Detection limit for 125147 is 0.1ng/ml as a capture antibody.
Mouse Anti-CNR2 Monoclonal Antibody, Testing Data – Cat# MBS6151882

Other Notes

Small volumes of anti-CNR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNR2 purchase

MBS6151882 is an antibody targeting CNR2. Also known as CNR2 (Cannabinoid Receptor 2, CB-2, CB2, hCB2, CX5) (HRP). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CNR2. It may not necessarily be applicable to this product.

NCBI GI #
4502929
NCBI GeneID
1269
NCBI Accession #
NP_001832.1
UniProt Primary Accession #
P34972
UniProt Secondary Accession #
Q4VBK8; Q5JRH7; Q6B0G7; Q6NSY0; C6ES44
UniProt Related Accession #
P34972
GenBank Nucleotide #
NM_001841.1
NCBI Official Full Name
cannabinoid receptor 2
NCBI Official Synonym Full Names
cannabinoid receptor 2 (macrophage)
NCBI Official Symbol
CNR2
NCBI Official Synonym Symbols
CB2; CX5; CB-2
UniProt Protein Name
Cannabinoid receptor 2
UniProt Synonym Protein Names
CX5
Protein Family
Cannabinoid receptor
UniProt Gene Name
CNR2
UniProt Synonym Gene Names
CB2A; CB2B; CB-2; CB2; hCB2
UniProt Entry Name
CNR2_HUMAN
NCBI Protein Information
cannabinoid receptor 2; testis-dominant CNR2 isoform CB2

NCBI Summary for CNR2

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
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UniProt Comments for CNR2

CNR2: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extrinsic to internal side of plasma membrane; integral to plasma membrane; dendrite; plasma membrane; perikaryon

Molecular Function: cannabinoid receptor activity

Biological Process: negative regulation of mast cell activation; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of nitric-oxide synthase activity; negative regulation of inflammatory response; response to amphetamine; response to lipopolysaccharide; immune response; negative regulation of action potential; negative regulation of synaptic transmission, GABAergic; inflammatory response; sensory perception of pain
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Research Articles on CNR2

1. In Burning mouth syndrome patients was increased TRPV1, decreased CB1 and increased CB2 expression in tongue epithelial cells also associated with a change in their distribution.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNR2 antibody

 Reference Product  PubMed Publications
 FAAH antibody  >16 publications with CNR2 and FAAH

Pathways associated with anti-CNR2 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-CNR2 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >47 publications with CNR2 and Pain
 Inflammation Antibodies  >41 publications with CNR2 and Inflammation
 Disease Models, Animal Antibodies  >35 publications with CNR2 and Disease Models, Animal
 Hyperalgesia Antibodies  >17 publications with CNR2 and Hyperalgesia
 Immune System Diseases Antibodies  >16 publications with CNR2 and Immune System Diseases
 Necrosis Antibodies  >14 publications with CNR2 and Necrosis
 Heart Diseases Antibodies  >12 publications with CNR2 and Heart Diseases
 Edema Antibodies  >10 publications with CNR2 and Edema
 Fibrosis Antibodies  >7 publications with CNR2 and Fibrosis
 Fatty Liver Antibodies  >4 publications with CNR2 and Fatty Liver

Organs/Tissues associated with anti-CNR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with CNR2 and Blood
 Liver Antibodies  >18 publications with CNR2 and Liver
 Bone Marrow Antibodies  >5 publications with CNR2 and Bone Marrow
 Placenta Antibodies  >2 publications with CNR2 and Placenta
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