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CTH Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6152004

MBS6152004 is an antibody targeting CTH. Also known as CTH (Cystathionine gamma-lyase, Cysteine-protein Sulfhydrase, Gamma-cystathionase) (HRP). Reactive in Human, Mouse. Host: Mouse. More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CTH, Monoclonal Antibody
Full Product Name
CTH (Cystathionine gamma-lyase, Cysteine-protein Sulfhydrase, Gamma-cystathionase) (HRP)
Product Gene Name
anti-CTH antibody
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
S51
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human CTH. Species Crossreactivity: mouse.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
41,260 Da
Immunogen
Full length recombinant corresponding to aa1-405 from human CTH (AAH15807) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGRSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
Conjugate
HRP

Product Categories/Family for anti-CTH antibody

Antibodies; Enzymes
Applications Tested/Suitable for anti-CTH antibody
ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-CTH antibody
IHC-P: 3ug/ml
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CTH antibody

Western Blot detection against Immunogen (70.07kD).
Mouse Anti-CTH Monoclonal Antibody – Cat# MBS6152004

Western Blot (WB) of anti-CTH antibody

CTH monoclonal antibody. Western Blot analysis of CTH expression in K-562.
Mouse Anti-CTH Monoclonal Antibody, Western Blot (WB) – Cat# MBS6152004

Western Blot (WB) of anti-CTH antibody

Western Blot analysis of CTH expression in transfected 293T cell line by CTH monoclonal antibody. Lane 1: CTH transfected lysate (45kD). Lane 2: Non-transfected lysate.
Mouse Anti-CTH Monoclonal Antibody, Western Blot (WB) – Cat# MBS6152004

Immunohistochemistry (IHC) of anti-CTH antibody

Immunoperoxidase of monoclonal antibody to CTH on formalin-fixed paraffin-embedded human pancreas. [antibody concentration 3ug/ml].
Mouse Anti-CTH Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6152004

Testing Data of anti-CTH antibody

Detection limit for recombinant GST tagged CTH is ~1ng/ml as a capture antibody.
Mouse Anti-CTH Monoclonal Antibody, Testing Data – Cat# MBS6152004

Product References and Citations for anti-CTH antibody

1. An investigation of the mechanisms of hydrogen sulfide-induced vasorelaxation in rat middle cerebral arteries. Streeter E, Hart J, Badoer E.Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul 17. 2. Characterization of Hydrogen Sulfide and Its Synthases, Cystathionine ?]-Synthase and Cystathionine ?^-Lyase, in Human Prostatic Tissue and Cells. Guo H, Gai JW, Wang Y, Jin HF, Du JB, Jin J.Urology. 2012 Feb;79(2):483.e1-5. 3. Glucocorticoids suppress cystathionine gamma-lyase expression and H(2)S production in lipopolysaccharide-treated macrophages. Zhu XY, Liu SJ, Liu YJ, Wang S, Ni X.Cell Mol Life Sci. 2010 Jan 10. 4. H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of KATP channels. Siebert N, Cantre D, Eipel C, Vollmar B.Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1266-73. Epub 2008 Oct 30.

Other Notes

Small volumes of anti-CTH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CTH. It may not necessarily be applicable to this product.

NCBI GI #
34194108
NCBI GeneID
1491
NCBI Accession #
BC015807
NCBI Related Accession #
AAH15807
UniProt Secondary Accession #
Q53FB3; Q53Y79; Q9H4W7; Q9H4W8; B4E1R2; E9PDV0
UniProt Related Accession #
P32929
NCBI Official Full Name
Homo sapiens cystathionase (cystathionine gamma-lyase), mRNA
NCBI Official Synonym Full Names
cystathionine gamma-lyase
NCBI Official Symbol
CTH
Protein Family
Cystathionine gamma-lyase
NCBI Protein Information
cystathionine gamma-lyase

NCBI Summary for CTH

This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
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Research Articles on CTH

1. Nox4 is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CTH antibody

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Formation From Homocysteine Pathway antibodies  Cysteine Formation From Homocysteine Pathway Diagram
 Degradation Of Cysteine And Homocysteine Pathway antibodies  Degradation Of Cysteine And Homocysteine Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram

Diseases associated with anti-CTH antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >83 publications with CTH and Nervous System Diseases
 Brain Diseases Antibodies  >67 publications with CTH and Brain Diseases
 Neoplasms Antibodies  >34 publications with CTH and Neoplasms
 Cardiovascular Diseases Antibodies  >34 publications with CTH and Cardiovascular Diseases
 Immune System Diseases Antibodies  >19 publications with CTH and Immune System Diseases
 Carcinoma Antibodies  >12 publications with CTH and Carcinoma
 Hypertrophy Antibodies  >10 publications with CTH and Hypertrophy
 Death Antibodies  >9 publications with CTH and Death
 Atrophy Antibodies  >8 publications with CTH and Atrophy
 Cognition Disorders Antibodies  >7 publications with CTH and Cognition Disorders

Organs/Tissues associated with anti-CTH antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >77 publications with CTH and Blood
 Brain Antibodies  >40 publications with CTH and Brain
 Bone Antibodies  >31 publications with CTH and Bone
 Kidney Antibodies  >15 publications with CTH and Kidney
 Muscle Antibodies  >12 publications with CTH and Muscle
 Liver Antibodies  >11 publications with CTH and Liver
 Testis Antibodies  >9 publications with CTH and Testis
 Lung Antibodies  >7 publications with CTH and Lung
 Eye Antibodies  >6 publications with CTH and Eye
 Connective Tissue Antibodies  >6 publications with CTH and Connective Tissue
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