Glutamate Transporter EAAT3 Antibody – Rabbit Polyclonal

Glutamate is the main excitatory neurotransmitter in the brain. To date five glutamate Transporters have been cloned: GLAST (EAAT1), GLT1 (EAAT2), EAAC1 (EAAT3), EAAT4, and EAAT5. These transporters are believed to be critical in reducing potentially toxic extracellular concentration of glutamate by rapid uptake into nerve terminals and glial cells. Glutamate transporters (525-573aa) display about 55% homology and are predicted to contain up to 6-10 transmembrane domains. Immunolocalization studies indicate that GLT1 is localized in astroglial cells throughout the brain and spinal cord. EAAC1 is specific for certain neurons and purkinje cells, and specifically enriched in cortex, hippocampus, and caudate-putamen and confined to presynaptic and postsynaptic elements. GLAST has been observed in both neuron and astroglia. It is most abundant in Bergmann glia, cortex, hippocampus and cerebellum. EAAT4 has properties of ligand gated Cl-channel. It is localized mainly in cerebellar Purkinje cells in rat and human CNS. EAAT5 has only been cloned from human. It is primarily expressed in retina.

• 1. Kiryu, S. et al (1995) J. Neurosci. 15:7872-7878; Kanai, Y. et al. (1994) J. Biol. Chem. 269:20599-20606; Mukainaka, Y. et al (1995) Biochim. Biophys. Acta 1244:233-2372. Rothstein, J. D. et al (1994) Neuron 13:713-725; Rothstein, J. D. et al (1995) Ann Neurol. 38:73-84

Small volumes of anti-Glutamate Transporter EAAT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS615255 is an antibody targeting Glutamate Transporter EAAT3. Also known as Anti - Glutamate Transporter EAAT3 (EAAC1). Reactive in Human, Mouse, Rabbit, Rat. Host: Rabbit
Source: Rat.