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PRDX3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6154326

Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRDX3, Monoclonal Antibody
Full Product Name
PRDX3 (Thioredoxin-dependent Peroxide Reductase, Mitochondrial, Antioxidant Protein 1, AOP-1, HBC189, Peroxiredoxin III, Prx-III, Peroxiredoxin-3, Protein MER5 Homolog, AOP1, MER5, MGC104387, MGC24293, PRO1748) (HRP)
Product Gene Name
anti-PRDX3 antibody
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
1E3-B2
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human PRDX3.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
25,839 Da
Immunogen
Full length recombinant corresponding to aa1-257 from human PRDX3 (AAH02685) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ
Conjugate
HRP

Product Categories/Family for anti-PRDX3 antibody

Antibodies; Enzymes; Peroxiredoxin
Applications Tested/Suitable for anti-PRDX3 antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-PRDX3 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-PRDX3 antibody

Western Blot analysis of PRDX3 expression in transfected 293T cell line by PRDX3 monoclonal antibody Lane 1: PRDX3 transfected lysate (27.7kD). Lane 2: Non-transfected lysate.
Mouse Anti-PRDX3 Monoclonal Antibody – Cat# MBS6154326

Immunofluorescence (IF) of anti-PRDX3 antibody

Immunofluorescence of monoclonal antibody to PRDX3 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-PRDX3 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS6154326

Immunoprecipitation (IP) of anti-PRDX3 antibody

Immunoprecipitation of PRDX3 transfected lysate using PRDX3 monoclonal antibody and Protein A Magnetic Bead and immunoblotted with PRDX3 rabbit polyclonal antibody.
Mouse Anti-PRDX3 Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS6154326

Testing Data of anti-PRDX3 antibody

Detection limit for recombinant GST tagged PRDX3 is ~1ng/ml as a capture antibody.
Mouse Anti-PRDX3 Monoclonal Antibody, Testing Data – Cat# MBS6154326

Other Notes

Small volumes of anti-PRDX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX3 purchase

MBS6154326 is an antibody targeting PRDX3. Also known as PRDX3 (Thioredoxin-dependent Peroxide Reductase, Mitochondrial, Antioxidant Protein 1, AOP-1, HBC189, Peroxiredoxin III, Prx-III, Peroxiredoxin-3, Protein MER5 Homolog, AOP1, MER5, MGC104387, MGC24293, PRO1748) (HRP). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX3. It may not necessarily be applicable to this product.

NCBI GI #
12803698
NCBI GeneID
10935
NCBI Accession #
BC002685
NCBI Related Accession #
AAH02685
UniProt Secondary Accession #
P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4; B2R7Z0; D3DRC9; E9PH29
UniProt Related Accession #
P30048
NCBI Official Full Name
Homo sapiens peroxiredoxin 3, mRNA
NCBI Official Synonym Full Names
peroxiredoxin 3
NCBI Official Symbol
PRDX3
NCBI Official Synonym Symbols
AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; prx-III
Protein Family
Thioredoxin-dependent peroxide reductase
NCBI Protein Information
thioredoxin-dependent peroxide reductase, mitochondrial

NCBI Summary for PRDX3

This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
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Research Articles on PRDX3

1. We also found that forkhead box protein 1 (FOXM1)-induced peroxiredoxin 3 (PRDX3) maintains the mitochondrial function, and the FOXM1/PRDX3 mitochondrial pathway maintains survival of colon CSCs

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PRDX3 antibody

 Products by Pathway  Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-PRDX3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >34 publications with PRDX3 and Neoplasms
 Necrosis Antibodies  >10 publications with PRDX3 and Necrosis
 Drug Toxicity Antibodies  >8 publications with PRDX3 and Drug Toxicity
 Inflammation Antibodies  >8 publications with PRDX3 and Inflammation
 Liver Diseases Antibodies  >7 publications with PRDX3 and Liver Diseases
 Nervous System Diseases Antibodies  >6 publications with PRDX3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >6 publications with PRDX3 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >5 publications with PRDX3 and Disease Models, Animal
 Prostatic Diseases Antibodies  >5 publications with PRDX3 and Prostatic Diseases
 Disease Progression Antibodies  >5 publications with PRDX3 and Disease Progression

Organs/Tissues associated with anti-PRDX3 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >8 publications with PRDX3 and Lung
 Kidney Antibodies  >4 publications with PRDX3 and Kidney
 Ovary Antibodies  >3 publications with PRDX3 and Ovary
 Uterus Antibodies  >2 publications with PRDX3 and Uterus
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