Neurite Outgrowth Inhibitor A (RTN4) Antibody – Rabbit Polyclonal

The capacity of the adult mammalian central nervous system (CNS) to repair lesions by axonal regeneration is very limited. However, CNS axons can extend for long distances in peripheral nerve grafts. CNS white matter selectively inhibits axonal outgrowth. Several components of CNS white matter, NI35, NI250 (Nogo) and MAG, that inhibit axon extension have been described. Neurite outgrowth inhibitor Nogo, also known as ASY and RTN-X, is a member of the reticulon (Rtn) family. Research on Nogo may be important in finding ways to promote nerve regeneration after stroke or spinal cord injury. Nogo induces apoptosis in various cancer cells when overexpressed so it may act to suppress tumor development. The nogo gene encodes at least three major protein products (Nogo-A, -B and -C). Nogo-A is the full-length protein (1192 aa). Nogo-B is the intermediate isoform that lacks amino acids 186-1004 within the extracellular domain (373 aa). Nogo-C, the shortest splice variant, also lacks amino acids 186-1004 but contains a smaller alternative N-terminal domain than Nogo-B. Nogo-A is also known as Reticulon 4-A, is expressed by oligodendrocytes but not by Schwann cells and associates with

Small volumes of anti-RTN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS615477 is an antibody targeting RTN4. Also known as Neurite Outgrowth Inhibitor A (NogoA). Reactive in Rat. Host: Rabbit.