SFTPC Antibody – Mouse Monoclonal

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

1. Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium. Wong AP, Keating A, Lu WY, Duchesneau P, Wang X, Sacher A, Hu J, Waddell TK.J Clin Invest. 2009 Feb;119(2):336-48. doi: 10.1172/JCI36882. Epub 2009 Jan 26.

Small volumes of anti-SFTPC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6154923 is an antibody targeting SFTPC. Also known as SFTPC (SFTP2, Pulmonary Surfactant-associated Protein C, Pulmonary Surfactant-associated Proteolipid SPL(Val), SP5) (HRP). Reactive in Human. Host: Mouse.