BACE2 Antibody – Rabbit Polyclonal

Beta-amyloid (Abeta) deposition in the brain is the hallmark of Alzheimer's Disease (AD). To initiate Ab formation, beta-secretase cleaves APP at the N-terminus of Ab to release APPsb (~100kD soluble NT-fragment), and C99, a 12-kD CT membrane fragment. Alternatively, alpha-secretase cleaves within the Ab to prevent the formation of Ab. Cleavage by a-secretase produces a soluble N-terminal fragment, APPsa, and a 10-kD membrane C-terminal fragment, C83. Both C99 and C83 can be further cleaved by gamma-secretase releasing Ab and a nonpathogenic p3 peptide, respectively.

• Saunders AJ et al (1999) Science 286, 1255; Fan W et al (1999) Science 286, 1256; Vassar R et al (1999) Science 286, 735-741; Yan R et al (1999) Nature 402, 533-537; Sinha S et al (1999) Nature 537-540; Hussain I et al (1999) Mol. Cell Neurosci. 14, 419-427; Lin X et al (2000) PNAS 97, 1456-1460.

Small volumes of anti-BACE2, Asp1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS615506 is an antibody targeting BACE2, Asp1. Also known as Anti - BACE2, Asp1 (Beta-Site APP Cleaving Enzyme 2). Reactive in Human. Host: Rabbit
Source: Human.