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TRAF1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6155503

Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of… More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRAF1, Monoclonal Antibody
Full Product Name
TRAF1 (TNF Receptor-associated Factor 1, Epstein-Barr Virus-induced Protein 6, EBI6) (HRP)
Product Gene Name
anti-TRAF1 antibody
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
2G9-G10
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human TRAF1.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
33,296 Da
Immunogen
Full length recombinant corresponding to aa1-416 from human TRAF1 (AAH24145) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALCCAGCLSENPRNGEDQICPKCRGEDLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETST
Conjugate
HRP

Product Categories/Family for anti-TRAF1 antibody

Antibodies; TRAF
Applications Tested/Suitable for anti-TRAF1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-TRAF1 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-TRAF1 antibody

Western Blot detection against Immunogen (71.5kD).
Mouse Anti-TRAF1 Monoclonal Antibody – Cat# MBS6155503

Testing Data of anti-TRAF1 antibody

Proximity Ligation Analysis of protein-protein interactions between TRAF2 and TRAF1 HeLa cells were stained with TRAF2 rabbit purified polyclonal 1:1200 and TRAF1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
Mouse Anti-TRAF1 Monoclonal Antibody, Testing Data – Cat# MBS6155503

Other Notes

Small volumes of anti-TRAF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRAF1 purchase

MBS6155503 is an antibody targeting TRAF1. Also known as TRAF1 (TNF Receptor-associated Factor 1, Epstein-Barr Virus-induced Protein 6, EBI6) (HRP). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TRAF1. It may not necessarily be applicable to this product.

NCBI GI #
33871045
NCBI GeneID
7185
NCBI Accession #
BC024145
UniProt Secondary Accession #
Q658U1; Q8NF13; B4DJ77
UniProt Related Accession #
Q13077
NCBI Official Full Name
Homo sapiens TNF receptor-associated factor 1, mRNA
NCBI Official Synonym Full Names
TNF receptor associated factor 1
NCBI Official Symbol
TRAF1
NCBI Official Synonym Symbols
EBI6; MGC:10353
Protein Family
TNF receptor-associated factor
NCBI Protein Information
TNF receptor-associated factor 1

NCBI Summary for TRAF1

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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Research Articles on TRAF1

1. Data suggest that, during B-cell transformation by Epstein-Barr virus, LMP1 (EBV latent membrane protein 1) induces signaling that stimulates Lys63-polyubiquitin chain attachment to TRAF1 (TNF receptor-associated factor 1) in the B-lymphocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TRAF1 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 EBV LMP1 Signaling Pathway antibodies  EBV LMP1 Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway antibodies  HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram

Diseases associated with anti-TRAF1 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >395 publications with TRAF1 and Necrosis
 Neoplasms Antibodies  >114 publications with TRAF1 and Neoplasms
 Arthritis, Rheumatoid Antibodies  >78 publications with TRAF1 and Arthritis, Rheumatoid
 Inflammation Antibodies  >57 publications with TRAF1 and Inflammation
 Carcinoma Antibodies  >27 publications with TRAF1 and Carcinoma
 Nervous System Diseases Antibodies  >18 publications with TRAF1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >15 publications with TRAF1 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >14 publications with TRAF1 and Cell Transformation, Neoplastic
 Lung Diseases Antibodies  >12 publications with TRAF1 and Lung Diseases
 Gastrointestinal Diseases Antibodies  >10 publications with TRAF1 and Gastrointestinal Diseases

Organs/Tissues associated with anti-TRAF1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >132 publications with TRAF1 and Blood
 Kidney Antibodies  >26 publications with TRAF1 and Kidney
 Skin Antibodies  >15 publications with TRAF1 and Skin
 Brain Antibodies  >15 publications with TRAF1 and Brain
 Lung Antibodies  >12 publications with TRAF1 and Lung
 Lymph Node Antibodies  >11 publications with TRAF1 and Lymph Node
 Lymph Antibodies  >10 publications with TRAF1 and Lymph
 Embryonic Tissue Antibodies  >7 publications with TRAF1 and Embryonic Tissue
 Eye Antibodies  >6 publications with TRAF1 and Eye
 Intestine Antibodies  >5 publications with TRAF1 and Intestine
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