Ephrin B1 (EPHB1) Antibody – Rabbit Polyclonal

EphB1: a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-B family: ephrin-B1, -B2 and -B3. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB1 interacts with GRB2, GRB10 and NCK through their respective SH2 domains. Four alternatively spliced isoforms are known.

Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, TK; TK group; Eph family

Cellular Component: filopodium tip; cell projection; membrane; axon; early endosome membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; endosome; lipid raft

Molecular Function: transmembrane-ephrin receptor activity; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; protein kinase activity; transferase activity; protein binding; protein-tyrosine kinase activity; ephrin receptor activity; transferase activity, transferring phosphorus-containing groups; protein complex binding; kinase activity; axon guidance receptor activity; ATP binding

Biological Process: axon guidance; nervous system development; peptidyl-tyrosine phosphorylation; formation of immunological synapse; protein amino acid autophosphorylation; cranial nerve development; central nervous system projection neuron axonogenesis; optic nerve morphogenesis; regulation of JNK cascade; protein amino acid phosphorylation; cell-substrate adhesion; positive regulation of synaptogenesis; camera-type eye morphogenesis; neurogenesis; establishment of cell polarity; ephrin receptor signaling pathway; angiogenesis; detection of temperature stimulus involved in sensory perception of pain; cell adhesion; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; retinal ganglion cell axon guidance