Alpha3, in (GFR) Antibody – Rabbit Polyclonal

Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin (1). Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb (2). Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3 (3-7). GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

Small volumes of anti-GFR alpha3, IN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS615812 is an antibody targeting GFR alpha3, IN. Also known as GFR alpha3, IN (Glycosylphosphadidylinositol linked Protein, GDNFRg, Ret ligand 3, RETL3). Reactive in Human, Mouse, Rat. Host: Rabbit.