IRS-2 (IRS2) Antibody – Rabbit Polyclonal

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq]

IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: plasma membrane; cytosol

Molecular Function: protein domain specific binding; protein binding; signal transducer activity; phosphoinositide 3-kinase binding; protein phosphatase binding; protein kinase binding; insulin receptor binding

Biological Process: negative regulation of kinase activity; regulation of lipid metabolic process; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; lipid homeostasis; signal transduction; positive regulation of glucose import; mammary gland development; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; positive regulation of B cell proliferation; response to glucose stimulus; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of insulin secretion; glucose metabolic process; positive regulation of fatty acid beta-oxidation; cell proliferation; cellular response to insulin stimulus; insulin receptor signaling pathway; innate immune response; brain development; negative regulation of B cell apoptosis; positive regulation of cell migration

Disease: Diabetes Mellitus, Noninsulin-dependent