Glycine Transporter-2 (slc6a5) Antibody – Rabbit Polyclonal

Function: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses

By similarity. UniProtKB Q9Y345

Subcellular location: Membrane; Multi-pass membrane protein

Potential.

Tissue specificity: First expressed in late neurula stages in the anterior spinal cord, where expression intensifies through the tailbud stages, and by hatching, expression is seen in the hindbrain. During late hatching stages, expression extends along most of the length of the spinal cord, mildly intensifies in the hindbrain, and appears in localized regions of the lateral forebrain and medial midbrain. By the swimming tadpole stage, weak expression appears in the anterior hindbrain, with stronger expression in the posterior, post-mitotic neurons. Ref.1

Sequence similarities: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily. [View classification]