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Artemin (ARTN) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS616173

Artemin is a novel member of the GDNF family and demonstrated that it is the ligand for the former orphan receptor GFRalpha3-RET. Artemin is a survival factor for sensory and sympathetic neurons in culture, and its expression pattern suggests that it also in… More details

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Product Overview

Online Datasheet in PDF
Product Name
Artemin (ARTN), Polyclonal Antibody
Full Product Name
Artemin, NT (GFRalpha3-RET Ligand)
Product Gene Name
anti-ARTN antibody
Product Synonym Names
Anti -Artemin, NT (GFRalpha3-RET Ligand)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide before the addition of glycerol to 40%.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Reacts with the N terminus of Artemin.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
22,878 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (44398992..44402912). Location: 1p33-p32
OMIM
603886
3D Structure
ModBase 3D Structure for Q5T4W7
Immunogen
N terminus of Artemin.

Product Categories/Family for anti-ARTN antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-ARTN antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ARTN antibody
Suitable for use in Western Blot and ELISA., , Recommended Dilution:, Western blot: 1:250 to 1:500, Optimal dilutions to be determined by the researcher.

Western Blot (WB) of anti-ARTN antibody

Western blot analysis of human Artemin in dorsal root ganglia/CNS preparation with anti-Artemin at a dilution of 1:500. Band at ~20kD. Primary antibody anti-Artemin (dilution 1:500) was incubated ON at 4°C. Secondary rabbit HRP antibody was incubated 1 hour at RT followed by ECL detection.
Rabbit Anti-ARTN Polyclonal Antibody – Cat# MBS616173

Other Notes

Small volumes of anti-ARTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARTN purchase

MBS616173 is an antibody targeting ARTN. Also known as Artemin, NT (GFRalpha3-RET Ligand). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARTN. It may not necessarily be applicable to this product.

NCBI GI #
4235100
NCBI GeneID
9048
UniProt Primary Accession #
Q5T4W7
UniProt Secondary Accession #
O95441; O96030; Q6P6A3; D3DPY1; D3DPY3
UniProt Related Accession #
Q5T4W7
NCBI Official Full Name
Artemin
NCBI Official Synonym Full Names
artemin
NCBI Official Symbol
ARTN
NCBI Official Synonym Symbols
EVN; NBN; ENOVIN
UniProt Protein Name
Artemin
UniProt Synonym Protein Names
Enovin; Neublastin
Protein Family
Artemin
UniProt Gene Name
ARTN
UniProt Synonym Gene Names
EVN
UniProt Entry Name
ARTN_HUMAN
NCBI Protein Information
artemin; neublastin; OTTHUMP00000009173; OTTHUMP00000231148; OTTHUMP00000231149; OTTHUMP00000231150; OTTHUMP00000231151; OTTHUMP00000231154; neurotrophic factor

NCBI Summary for ARTN

The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for ARTN

artemin: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Belongs to the TGF-beta family. GDNF subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; receptor binding

Biological Process: axon guidance; neuroblast proliferation; signal transduction; peripheral nervous system development; induction of positive chemotaxis
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Research Articles on ARTN

1. Forced expression of ARTN in ER-positive human mammary carcinoma cells increased ER transcriptional activity, promoted estrogen-independent growth and produced resistance to tamoxifen.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ARTN antibody

 Reference Product  PubMed Publications
 GFRA3 antibody  >14 publications with ARTN and GFRA3

Pathways associated with anti-ARTN antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram

Diseases associated with anti-ARTN antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >9 publications with ARTN and Carcinoma
 Spinal Cord Injuries Antibodies  >5 publications with ARTN and Spinal Cord Injuries
 Hyperalgesia Antibodies  >5 publications with ARTN and Hyperalgesia
 Adenocarcinoma Antibodies  >4 publications with ARTN and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >3 publications with ARTN and Neoplasm Metastasis
 Inflammation Antibodies  >3 publications with ARTN and Inflammation
 Breast Neoplasms Antibodies  >2 publications with ARTN and Breast Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with ARTN and Congenital Abnormalities
 Female Urogenital Diseases Antibodies  >1 publications with ARTN and Female Urogenital Diseases
 Melanoma Antibodies  >1 publications with ARTN and Melanoma

Organs/Tissues associated with anti-ARTN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with ARTN and Brain
 Pancreas Antibodies  >4 publications with ARTN and Pancreas
 Kidney Antibodies  >4 publications with ARTN and Kidney
 Intestine Antibodies  >4 publications with ARTN and Intestine
 Lung Antibodies  >2 publications with ARTN and Lung
 Esophagus Antibodies  >1 publications with ARTN and Esophagus
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