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ILKAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS616200

Integrin-linked kinases (ILKs) couple integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility (1). ILK functions as a scaffold bridging the extra-cellular matrix (ECM) and growth… More details

$820 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ILK1 (ILKAP), Polyclonal Antibody
Full Product Name
ILK1 (Integrin Linked Kinase)
Product Gene Name
anti-ILKAP antibody
Product Synonym Names
Anti -ILK1 (Integrin Linked Kinase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Bovine, Human, Monkey, Mouse, Rat
Form/Format
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes endogenous levels of total human ILK1 at ~51kD. May crossreact with ILK2. Species Crossreactivity: mouse, rat, monkey and bovine
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Molecular Weight
42,907 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (239079043..239112343, complement). Location: 2q37.3
3D Structure
ModBase 3D Structure for Q9H0C8
Immunogen
Synthetic peptide corresponding to the C-terminus of human ILK1.

Product Categories/Family for anti-ILKAP antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-ILKAP antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ILKAP antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:1000
Immunohistochemistry (Paraffin): 1:100

Western Blot (WB) of anti-ILKAP antibody

Western blot analysis of extracts from HeLa, NIH/3T3, COS, PC12 and C6 cells, using IMBS616200.
Rabbit Anti-ILKAP Polyclonal Antibody – Cat# MBS616200

Immunohistochemistry (IHC) of anti-ILKAP antibody

Immunohistochemical staining of ILK1 in paraffin-embedded human breast carcinoma showing cytoplasmic localization, using IMBS616200.
Rabbit Anti-ILKAP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS616200

Other Notes

Small volumes of anti-ILKAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ILKAP purchase

MBS616200 is an antibody targeting ILKAP. Also known as ILK1 (Integrin Linked Kinase). Reactive in Bovine, Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ILKAP. It may not necessarily be applicable to this product.

NCBI GI #
13540531
NCBI GeneID
80895
NCBI Accession #
NP_110395.1
UniProt Primary Accession #
Q9H0C8
UniProt Secondary Accession #
B3KM39
UniProt Related Accession #
Q9H0C8
GenBank Nucleotide #
NM_030768.2
NCBI Official Full Name
integrin-linked kinase-associated serine/threonine phosphatase 2C
NCBI Official Synonym Full Names
integrin-linked kinase-associated serine/threonine phosphatase
NCBI Official Symbol
ILKAP
NCBI Official Synonym Symbols
ILKAP2; ILKAP3; PP2C-DELTA
UniProt Protein Name
Integrin-linked kinase-associated serine/threonine phosphatase 2C
Protein Family
Integrin-linked kinase-associated serine/threonine phosphatase
UniProt Gene Name
ILKAP
UniProt Synonym Gene Names
ILKAP
UniProt Entry Name
ILKAP_HUMAN
NCBI Protein Information
integrin-linked kinase-associated serine/threonine phosphatase 2C; protein phosphatase 2c, delta isozyme; integrin-linked kinase associated phosphatase

NCBI Summary for ILKAP

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
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UniProt Comments for ILKAP

ILKAP: a protein serine/threonine phosphatase of the PP2C family. Can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cytoplasm

Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: protein amino acid dephosphorylation; regulation of DNA replication during S phase
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Research Articles on ILKAP

1. ILKAP is a nuclear protein that regulates cell survival and apoptosis through the regulation of RSK2 signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ILKAP antibody

 Reference Product  PubMed Publications
 ILK antibody  >4 publications with ILKAP and ILK

Diseases associated with anti-ILKAP antibody

 Disease Name  Pubmed Publications
 Ataxia Antibodies  >1 publications with ILKAP and Ataxia
 Nervous System Diseases Antibodies  >1 publications with ILKAP and Nervous System Diseases

Organs/Tissues associated with anti-ILKAP antibody

 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >2 publications with ILKAP and Mouth
 Blood Antibodies  >2 publications with ILKAP and Blood
 Prostate Antibodies  >1 publications with ILKAP and Prostate
 Kidney Antibodies  >1 publications with ILKAP and Kidney
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