MAPK7 Antibody – Sheep Polyclonal

ERK5: a protein kinase of the MAPK family. Phosphorylated and activated by MEK5. Involved in the signaling processes downstream of various receptors including receptor tyrosine kinases and G protein-coupled receptors. Translocates to cell nucleus in response to extracelluar signals, where it regulates gene expression by phosphorylating various transcription factors. Mouse knockout shows a role in development and integrity of blood vessels. May block apoptosis in endothelial cells. Required for transduction of EGF growth signal, constitutively activated in ErbB2-overexpressing breast cancer, and downstream of activated Mek5 in metastatic prostate cancerFour alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

Protein type: EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Kinase, protein; CMGC group; MAPK family; ERK subfamily; MAPK/ERK subfamily

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; PML body; cytoplasm; nucleus; cytosol

Molecular Function: MAP kinase activity; protein binding; mitogen-activated protein kinase binding; ATP binding

Biological Process: negative regulation of cAMP catabolic process; nerve growth factor receptor signaling pathway; negative regulation of heterotypic cell-cell adhesion; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; negative regulation of NFAT protein import into nucleus; cell cycle; positive regulation of protein metabolic process; regulation of angiogenesis; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; cAMP-mediated signaling; negative regulation of inflammatory response; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; cell differentiation; negative regulation of cyclic-nucleotide phosphodiesterase activity; toll-like receptor 4 signaling pathway