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2019-03-06 (MARCH6) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6163931

MBS6163931 is an antibody targeting MARCH6. Also known as MARCH6 (Membrane-Associated Ring Finger (C3HC4) 6, KIAA0597, MARCH-VI, RNF176, TEB4) (AP). Host: Mouse. Mouse monoclonal antibody raised against a partial recombinant MARCH6. More details

$995 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
2019-03-06 (MARCH6), Monoclonal Antibody
Full Product Name
MARCH6 (Membrane-Associated Ring Finger (C3HC4) 6, KIAA0597, MARCH-VI, RNF176, TEB4) (AP)
Product Gene Name
Product Synonym Names
Membrane-Associated Ring Finger (C3HC4) 6; KIAA0597; MARCH-VI; RNF176; TEB4
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
1A5
Host
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified
Specificity
Recognizes MARCH6.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
613297
3D Structure
ModBase 3D Structure for O60337
Immunogen
MARCH6 (NP_005876, 2aa-91aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
DTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIR
Conjugate
AP
Applications Tested/Suitable for anti-MARCH6 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-MARCH6 antibody
Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-MARCH6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MARCH6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
E3 ubiquitin-protein ligase MARCH6 isoform 1
NCBI Official Synonym Full Names
membrane associated ring-CH-type finger 6
NCBI Official Symbol
MARCHF6
NCBI Official Synonym Symbols
TEB4; DOA10; FAME3; MARCH6; RNF176; MARCH-VI
UniProt Protein Name
E3 ubiquitin-protein ligase MARCH6
UniProt Synonym Protein Names
Doa10 homolog; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI; MARCH-VI; Protein TEB-4; RING finger protein 176
UniProt Gene Name
MARCH6
UniProt Synonym Gene Names
KIAA0597; RNF176; TEB4; MARCH-VI
UniProt Entry Name
MARH6_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase MARCH6

NCBI Summary for MARCH6

This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
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UniProt Comments for MARCH6

MARCH6: E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Protein type: Membrane protein, multi-pass; Ubiquitin conjugating system; Membrane protein, integral; Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Ligase

Chromosomal Location of Human Ortholog: 5p15.2

Cellular Component: membrane; integral to endoplasmic reticulum membrane

Molecular Function: enzyme binding; ubiquitin conjugating enzyme binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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