Rabbit Anti-RGS3 Polyclonal Antibody – Cat# MBS616454

RGS3 Antibody – Rabbit Polyclonal

Name: RGS3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS616454
Price: 640 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS616454

RGS3 (regulator of G protein signaling 3) is a 519-residue protein that is widely expressed. The protein contains an RGS domain near the carboxy terminus that serves as a GTPase-activating protein (GAP). RGS3 negatively regulates the activation of Gi and Gq.… More details

$640 / 0.2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RGS3, Polyclonal Antibody

Full Product Name

RGS3 (Regulator of G protein signaling 3)

Product Gene Name

anti-RGS3 antibody

Product Synonym Names

Anti -RGS3 (Regulator of G protein signaling 3)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder in 0.1% sodium azide. Reconstitute to 1mg/ml by adding 200ul PBS.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Reacts with the RGS3 protein. Crossreacts with RGS3T, a N-terminal truncated form of RGS3.

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

132,336 Da

Chromosome Location

Chromosome: 9; NC_000009.11 (116207011..116360018). Location: 9q32

OMIM

602189

3D Structure

ModBase 3D Structure for P49796

Immunogen

E. coli-expressed human RGS3 (aa 401-519; corresponding to the C-terminal 119 residues)

Product Categories/Family for anti-RGS3 antibody

Antibodies; Abs to G Proteins

Applications Tested/Suitable for anti-RGS3 antibody

Western Blot (WB), Immunoprecipitation (IP)

Application Notes for anti-RGS3 antibody

Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1:5000

Other Notes

Small volumes of anti-RGS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RGS3 purchase

MBS616454 is an antibody targeting RGS3. Also known as RGS3 (Regulator of G protein signaling 3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RGS3. It may not necessarily be applicable to this product.

NCBI GI #

55664618

NCBI GeneID

5998

UniProt Primary Accession #

P49796

UniProt Secondary Accession #

Q5VXB8; Q5VXC1; Q5VZ05; Q6ZRM5; Q8IUQ1; Q8NC47; Q8NFN4; Q8NFN5; Q8TD59; A6NHA0; A8K0V1

UniProt Related Accession #

P49796; Q53GP3; Q5VXC0; Q5VZ06; Q6ZV17; Q8NFN6; Q8WV02; Q8WVE9; Q96NV5; Q9NX91

NCBI Official Full Name

regulator of G-protein signaling 3

NCBI Official Synonym Full Names

regulator of G-protein signaling 3

NCBI Official Symbol

RGS3

NCBI Official Synonym Symbols

C2PA; RGP3; FLJ20370; FLJ31516; FLJ90496; PDZ-RGS3

UniProt Protein Name

Regulator of G-protein signaling 3

Protein Family

Regulator of G-protein signaling

UniProt Gene Name

RGS3

UniProt Entry Name

RGS3_HUMAN

NCBI Protein Information

regulator of G-protein signaling 3; OTTHUMP00000022812; OTTHUMP00000022813; OTTHUMP00000022814; OTTHUMP00000022815; OTTHUMP00000215341; OTTHUMP00000215342; OTTHUMP00000233952; regulator of G-protein signalling 3

NCBI Summary for RGS3

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known. [provided by RefSeq]

UniProt Comments for RGS3

RGS3: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol

Molecular Function: GTPase activator activity

Biological Process: regulation of G-protein coupled receptor protein signaling pathway; inactivation of MAPK activity; positive regulation of GTPase activity

Research Articles on RGS3

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RGS3 antibody

Reference Product	PubMed Publications
EFNB1 antibody	>1 publications with RGS3 and EFNB1

Pathways associated with anti-RGS3 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
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Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram
Ephrin B Reverse Signaling Pathway antibodies	Ephrin B Reverse Signaling Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram

Diseases associated with anti-RGS3 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>11 publications with RGS3 and Cardiovascular Diseases
Heart Failure Antibodies	>9 publications with RGS3 and Heart Failure
Hypertrophy Antibodies	>6 publications with RGS3 and Hypertrophy
Cardiomegaly Antibodies	>2 publications with RGS3 and Cardiomegaly
Carcinoma Antibodies	>2 publications with RGS3 and Carcinoma
Adenocarcinoma Antibodies	>2 publications with RGS3 and Adenocarcinoma
Hypotension Antibodies	>1 publications with RGS3 and Hypotension
Bone Marrow Diseases Antibodies	>1 publications with RGS3 and Bone Marrow Diseases
Ventricular Remodeling Antibodies	>1 publications with RGS3 and Ventricular Remodeling
Cell Transformation, Neoplastic Antibodies	>1 publications with RGS3 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-RGS3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>23 publications with RGS3 and Brain
Heart Antibodies	>21 publications with RGS3 and Heart
Muscle Antibodies	>20 publications with RGS3 and Muscle
Kidney Antibodies	>8 publications with RGS3 and Kidney
Vascular Antibodies	>8 publications with RGS3 and Vascular
Ovary Antibodies	>4 publications with RGS3 and Ovary
Nerve Antibodies	>4 publications with RGS3 and Nerve
Lung Antibodies	>3 publications with RGS3 and Lung
Blood Antibodies	>3 publications with RGS3 and Blood
Embryonic Tissue Antibodies	>2 publications with RGS3 and Embryonic Tissue