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BLOC1S2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6165401

BLOC1S2 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BLOC1S2, Monoclonal Antibody
Full Product Name
BLOC1S2 (Biogenesis of Lysosomal Organelles Complex-1, Subunit 2, BLOS2, FLJ30135, MGC10120, RP11-316M21.4) (AP)
Product Gene Name
anti-BLOC1S2 antibody
Product Synonym Names
Biogenesis of Lysosomal Organelles Complex-1; Subunit 2; BLOS2; FLJ30135; MGC10120; RP11-316M21.4
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
8C10
Host
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified
Specificity
Recognizes BLOC1S2.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
18.5 kDa
OMIM
609768
3D Structure
ModBase 3D Structure for Q6QNY1
Immunogen
BLOC1S2 (NP_776170.2, 1aa-142aa) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Conjugate
AP

Product Categories/Family for anti-BLOC1S2 antibody

Antibodies; Organelle Markers
Applications Tested/Suitable for anti-BLOC1S2 antibody
Western Blot (WB)
Application Notes for anti-BLOC1S2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-BLOC1S2 antibody

Western Blot analysis of BLOC1S2 expression in transfected 293T cell line by BLOC1S2 monoclonal antibody (M01), clone 8C10.

Lane 1: BLOC1S2 transfected lysate (Predicted MW: 16 KDa).
Lane 2: Non-transfected lysate.
Mouse Anti-BLOC1S2 Monoclonal Antibody – Cat# MBS6165401

Testing Data of anti-BLOC1S2 antibody

Detection limit for recombinant GST tagged BLOC1S2 is 0.03 ng/ml as a capture antibody.
Mouse Anti-BLOC1S2 Monoclonal Antibody, Testing Data – Cat# MBS6165401

Other Notes

Small volumes of anti-BLOC1S2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BLOC1S2 purchase

MBS6165401 is an antibody targeting BLOC1S2. Also known as BLOC1S2 (Biogenesis of Lysosomal Organelles Complex-1, Subunit 2, BLOS2, FLJ30135, MGC10120, RP11-316M21.4) (AP). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for BLOC1S2. It may not necessarily be applicable to this product.

NCBI GI #
46852398
NCBI GeneID
282991
NCBI Accession #
NP_776170.2
UniProt Primary Accession #
Q6QNY1
UniProt Secondary Accession #
Q5W040; Q8WUI8; B4DQV2
UniProt Related Accession #
Q6QNY1
GenBank Nucleotide #
NM_173809.4
NCBI Official Full Name
biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1
NCBI Official Synonym Full Names
biogenesis of lysosomal organelles complex-1, subunit 2
NCBI Official Symbol
BLOC1S2
NCBI Official Synonym Symbols
CEAP; BLOS2; CEAP11
UniProt Protein Name
Biogenesis of lysosome-related organelles complex 1 subunit 2
UniProt Synonym Protein Names
Centrosome-associated protein
Protein Family
Biogenesis of lysosome-related organelles complex
UniProt Gene Name
BLOC1S2
UniProt Synonym Gene Names
BLOS2; CEAP; BLOC-1 subunit 2
UniProt Entry Name
BL1S2_HUMAN
NCBI Protein Information
biogenesis of lysosome-related organelles complex 1 subunit 2

UniProt Comments for BLOC1S2

BLOC1S2: May play a role in cell proliferation. The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Belongs to the BLOC1S2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 10q24.31

Cellular Component: centrosome; recycling endosome; mitochondrion; nucleus; gamma-tubulin complex

Molecular Function: protein C-terminus binding; protein binding; gamma-tubulin binding

Biological Process: induction of apoptosis via death domain receptors; platelet dense granule organization and biogenesis; melanosome organization and biogenesis; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; anterograde synaptic vesicle transport; positive regulation of transcription from RNA polymerase II promoter; microtubule nucleation; anterograde axon cargo transport; neurite development
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BLOC1S2 antibody

 Reference Product  PubMed Publications
 BLOC1S3 antibody  >6 publications with BLOC1S2 and BLOC1S3
 BLOC1S1 antibody  >5 publications with BLOC1S2 and BLOC1S1
 MUTED antibody  >2 publications with BLOC1S2 and MUTED
 PLDN antibody  >2 publications with BLOC1S2 and PLDN
 DTNBP1 antibody  >2 publications with BLOC1S2 and DTNBP1
 SNAPIN antibody  >1 publications with BLOC1S2 and SNAPIN

Diseases associated with anti-BLOC1S2 antibody

 Disease Name  Pubmed Publications
 Eye Diseases Antibodies  >7 publications with BLOC1S2 and Eye Diseases
 Necrosis Antibodies  >1 publications with BLOC1S2 and Necrosis

Organs/Tissues associated with anti-BLOC1S2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with BLOC1S2 and Liver
 Eye Antibodies  >2 publications with BLOC1S2 and Eye
 Blood Antibodies  >2 publications with BLOC1S2 and Blood
 Uncharacterized Tissue Antibodies  >1 publications with BLOC1S2 and Uncharacterized Tissue
 Kidney Antibodies  >1 publications with BLOC1S2 and Kidney
 Bone Antibodies  >1 publications with BLOC1S2 and Bone
 Muscle Antibodies  >1 publications with BLOC1S2 and Muscle
 Spleen Antibodies  >1 publications with BLOC1S2 and Spleen
 Testis Antibodies  >1 publications with BLOC1S2 and Testis
 Skin Antibodies  >1 publications with BLOC1S2 and Skin
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