Nogo Receptor 3 Antibody – Rabbit Polyclonal

Many tissues such as muscle, skin, liver, and peripheral nerve, have remarkable ability to repair and regrow after injury. However, the CNS (brain and spinal cord) is limited in its ability to repair or regrowth causing permanent brain damage or paralyses. Most recently an inhibitory myelin protein, Nogo (Neurite outgrowth), has been cloned and characterized. It may help block the regeneration of the CNS. Recently, a brain specific leucine-rich-repeat protein with high affinity for soluble Nogo-66, termed Nogo receptor (Ngr) has been cloned and characterized. Cleavage of Ngr from the axonal surface renders neurons insensitive to Nogo-66. Ngr expression is sufficient to impart Nogo-66 axonal inhibition to unresponsive neurons. Ngr is expressed in brain and lower levels are also detected in hear and kidney but not in other peripheral tissues. Additional proteins homologous to Ngr have now been identified and designated NGR2 or NgRH1 (nogo-66 receptor homolog-1; human and rat 420 aa; chromosome 11q12.1) and Ngr3 or NgRH2 (nogo-66 receptor homolog-2; rat 438 aa; mouse, 445 aa; human 441 aa, chromosome 17p13.3). There is approx. 45% sequence homology between the NGR1-3. Despite high degree of sequence homology and similar protein topology, the NGR2 and NGR3 do not bind Nogo, MAG, Omgp or NGR1. The identity of other natural ligands for NGR2-3, and the physiological roles of NGR2-3 are unknown. Both NGR2 and NGR3 are expressed in the brain. The NGR2-3 proteins appeared as ~45 and ~65 kda protein (glycosylated).

• 1.  Pignot V et al (2003) J Neurochem. 85, 717-728; EMBO J (2003) 22, 3291-3303; Fournier AE et al (2001) Nature 409, 341-346,  Chen MS et al (2000) Nature 403, 434-439;  GrandPre T et al (2000) Nature 403; 439-444;  Goldberg JL and Barres BA (2000) Nature 403; 369-370;  Prinjha R et al (2000) Nature 403, 383-384;  Tessier-Lavigne M and Goodman CS (2000) Science 287, 813-814; Nagase T et al (1998) DNA Res. 5, 355-364

Small volumes of anti-Nogo Receptor 3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS616648 is an antibody targeting Nogo Receptor 3. Also known as Anti - Nogo Receptor 3 (Ngr3/NgRH2). Reactive in Human. Host: Rabbit
Source: Human.