LHX6 Antibody – Mouse Monoclonal

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]

LHX6: Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity; zinc ion binding

Biological Process: cell maturation; cerebral cortex GABAergic interneuron migration; cerebral cortex radially oriented cell migration; cerebral cortex tangential migration; forebrain neuron fate commitment; regulation of transcription, DNA-dependent; transcription, DNA-dependent