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Plexin D1 (PLXND1) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS616656

Plexin D1 is a type I transmembrane protein that is the prototype of the Plexin D subfamily in the Plexin family. It is expressed on multiple tissues including fetal neuronal and endothelial cells. Plexin D1 expression is also induced on tumor vasculature and… More details

$1135 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Plexin D1 (PLXND1), Polyclonal Antibody
Full Product Name
Plexin D1 (Biotin)
Product Gene Name
anti-PLXND1 antibody
Product Synonym Names
Anti -Plexin D1 (Biotin)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from PBS with BSA. Labeled with biotin. Reconstitute with 1ml TBS, pH7.3, containing 0.1% BSA to a concentration of 0.05mg/ml.
Purity/Purification
Affinity Purified
Purified by human Plexin D1 affinity chromatography.
Specificity
Recognizes human Plexin D1 extracellular domain. Species sequence homology: Mouse 89% and canine 91%.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
212,007 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (129274056..129325582, complement). Location: 3q22.1
OMIM
604282
3D Structure
ModBase 3D Structure for Q9Y4D7
Immunogen
NS0-derived recombinant human rhPlexin D1 extracellular domain.
Hybridoma
Produced in a goat immunized with purified, NS0-derived, recombinant human Plexin D1 extracellular domain (rhPlexin D1; aa 47-1271).

Product Categories/Family for anti-PLXND1 antibody

Antibodies; Abs to Plexin; Semaphorin
Applications Tested/Suitable for anti-PLXND1 antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-PLXND1 antibody
Suitable for use in Western Blot and Flow cytometry.
Dilution: Western blot: 0.1 0.2ug/ml. The detection limit is~1ng/lane under non-reducing and reducing conditions.
Flow cytometry: 25ug/ml. Add 10il of the diluted solution to 1-2.5 x 10e5 cells in a total reaction volume not exceeding 200ul. The binding of biotinylated antibodies may be visualized by adding a secondary developing reagent such as streptavidin conjugated to a fluorochrome.

Other Notes

Small volumes of anti-PLXND1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLXND1 purchase

MBS616656 is an antibody targeting PLXND1. Also known as Plexin D1 (Biotin). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for PLXND1. It may not necessarily be applicable to this product.

NCBI GI #
157694524
NCBI GeneID
23129
NCBI Accession #
NP_055918.2
UniProt Primary Accession #
Q9Y4D7
UniProt Secondary Accession #
Q6PJS9; Q8IZJ2; Q9BTQ2; A7E2C6; C9JPZ6
UniProt Related Accession #
Q6P657; Q86YC4; Q9Y4D7
GenBank Nucleotide #
NM_015103.2
NCBI Official Full Name
plexin-D1
NCBI Official Synonym Full Names
plexin D1
NCBI Official Symbol
PLXND1
NCBI Official Synonym Symbols
PLEXD1; KIAA0620; MGC75353
UniProt Protein Name
Plexin-D1
Protein Family
Plexin
UniProt Gene Name
PLXND1
UniProt Synonym Gene Names
KIAA0620
UniProt Entry Name
PLXD1_HUMAN
NCBI Protein Information
plexin-D1; OTTHUMP00000215785

UniProt Comments for PLXND1

PLXND1: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature. Mediates anti-angiogenic signaling in response to SEMA3E. Belongs to the plexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: integral to plasma membrane; lamellipodium; plasma membrane; intracellular

Molecular Function: protein domain specific binding; protein binding; semaphorin receptor activity

Biological Process: patterning of blood vessels; axon guidance; synaptogenesis; positive regulation of protein binding; endothelial cell migration; angiogenesis; regulation of cell migration; regulation of angiogenesis
Show more

Research Articles on PLXND1

1. Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLXND1 antibody

 Reference Product  PubMed Publications
 SEMA4A antibody  >1 publications with PLXND1 and SEMA4A
 NRP1 antibody  >1 publications with PLXND1 and NRP1

Pathways associated with anti-PLXND1 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-PLXND1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with PLXND1 and Neoplasms
 Nervous System Diseases Antibodies  >3 publications with PLXND1 and Nervous System Diseases
 Opportunistic Infections Antibodies  >1 publications with PLXND1 and Opportunistic Infections
 Neoplasms, Experimental Antibodies  >1 publications with PLXND1 and Neoplasms, Experimental
 Endometrial Neoplasms Antibodies  >1 publications with PLXND1 and Endometrial Neoplasms
 Heart Diseases Antibodies  >1 publications with PLXND1 and Heart Diseases
 Hypertension Antibodies  >1 publications with PLXND1 and Hypertension

Organs/Tissues associated with anti-PLXND1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >12 publications with PLXND1 and Vascular
 Blood Antibodies  >11 publications with PLXND1 and Blood
 Nerve Antibodies  >8 publications with PLXND1 and Nerve
 Embryonic Tissue Antibodies  >4 publications with PLXND1 and Embryonic Tissue
 Brain Antibodies  >4 publications with PLXND1 and Brain
 Muscle Antibodies  >2 publications with PLXND1 and Muscle
 Liver Antibodies  >2 publications with PLXND1 and Liver
 Thymus Antibodies  >1 publications with PLXND1 and Thymus
 Skin Antibodies  >1 publications with PLXND1 and Skin
 Lymph Node Antibodies  >1 publications with PLXND1 and Lymph Node
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