• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

NR2E1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6166571

MBS6166571 is an antibody targeting NR2E1. Also known as NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1, TLL, TLX, XTLL) (APC). Host: Mouse. Mouse monoclonal antibody raised against a partial recombinant NR2E1. More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NR2E1, Monoclonal Antibody
Full Product Name
NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1, TLL, TLX, XTLL) (APC)
Product Gene Name
anti-NR2E1 antibody
Product Synonym Names
Nuclear Receptor Subfamily 2; Group E; Member 1; TLL; TLX; XTLL
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
4D2
Host
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified
Specificity
Recognizes NR2E1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
42kDa
OMIM
603849
3D Structure
ModBase 3D Structure for Q9Y466
Immunogen
NR2E1 (NP_003260, 249aa-342aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Conjugate
APC

Product Categories/Family for anti-NR2E1 antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-NR2E1 antibody
ELISA (EIA), Immunofluorescence (IF)
Application Notes for anti-NR2E1 antibody
Applications are based on unconjugated antibody.

Immunofluorescence (IF) of anti-NR2E1 antibody

Immunofluorescence of monoclonal antibody to NR2E1 on NIH/3T3 cell. [antibody concentration 10 ug/ml]
Mouse Anti-NR2E1 Monoclonal Antibody – Cat# MBS6166571

Immunofluorescence (IF) of anti-NR2E1 antibody

Immunofluorescence of monoclonal antibody to NR2E1 on NIH/3T3 cell. [antibody concentration 10 ug/ml]
Mouse Anti-NR2E1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS6166571

Other Notes

Small volumes of anti-NR2E1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NR2E1. It may not necessarily be applicable to this product.

NCBI GI #
4507537
NCBI GeneID
7101
NCBI Accession #
NP_003260
UniProt Primary Accession #
Q9Y466
UniProt Related Accession #
Q9Y466
GenBank Nucleotide #
NM_003269
NCBI Official Full Name
nuclear receptor subfamily 2 group E member 1 isoform b
NCBI Official Synonym Full Names
nuclear receptor subfamily 2 group E member 1
NCBI Official Symbol
NR2E1
NCBI Official Synonym Symbols
TLL; TLX; XTLL
UniProt Protein Name
Nuclear receptor subfamily 2 group E member 1
UniProt Synonym Protein Names
Nuclear receptor TLX; Protein tailless homolog; Tll; hTll
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
NR2E1
UniProt Synonym Gene Names
TLX; Tll; hTll
UniProt Entry Name
NR2E1_HUMAN
NCBI Protein Information
nuclear receptor subfamily 2 group E member 1

NCBI Summary for NR2E1

The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Show more

UniProt Comments for NR2E1

NR2E1: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acic receptor (RAR) regulation in retinal cells. Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: nucleoplasm

Molecular Function: zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; steroid hormone receptor activity

Biological Process: extracellular matrix organization and biogenesis; behavioral fear response; somatic stem cell maintenance; regulation of dendrite morphogenesis; regulation of timing of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; amygdala development; cerebral cortex neuron differentiation; visual perception; layer formation in the cerebral cortex; nervous system development; transcription initiation from RNA polymerase II promoter; dentate gyrus development; cell fate commitment; generation of neurons in the forebrain; olfactory bulb development; positive regulation of cell cycle; social behavior; negative regulation of neuron differentiation; positive regulation of angiogenesis; anterior commissure morphogenesis; retina development in camera-type eye; negative regulation of astrocyte differentiation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis
Show more

Research Articles on NR2E1

1. ASK1 phosphorylated and stabilized TLX, which led induction of HIF-1alpha, and its downstream VEGF-A in an Akt dependent manner.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR2E1 antibody

 Reference Product  PubMed Publications
 NR4A2 antibody  >2 publications with NR2E1 and NR4A2
 NR0B2 antibody  >1 publications with NR2E1 and NR0B2
 NR5A1 antibody  >1 publications with NR2E1 and NR5A1
 NR2C1 antibody  >1 publications with NR2E1 and NR2C1
 NR1D1 antibody  >1 publications with NR2E1 and NR1D1

Pathways associated with anti-NR2E1 antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram

Diseases associated with anti-NR2E1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >10 publications with NR2E1 and Congenital Abnormalities
 Eye Abnormalities Antibodies  >6 publications with NR2E1 and Eye Abnormalities
 Musculoskeletal Abnormalities Antibodies  >2 publications with NR2E1 and Musculoskeletal Abnormalities
 Craniofacial Abnormalities Antibodies  >2 publications with NR2E1 and Craniofacial Abnormalities
 Glioblastoma Antibodies  >2 publications with NR2E1 and Glioblastoma
 Abnormalities, Multiple Antibodies  >2 publications with NR2E1 and Abnormalities, Multiple
 Growth Disorders Antibodies  >1 publications with NR2E1 and Growth Disorders
 Embryo Loss Antibodies  >1 publications with NR2E1 and Embryo Loss
 Necrosis Antibodies  >1 publications with NR2E1 and Necrosis
 Inflammation Antibodies  >1 publications with NR2E1 and Inflammation

Organs/Tissues associated with anti-NR2E1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >52 publications with NR2E1 and Brain
 Eye Antibodies  >17 publications with NR2E1 and Eye
 Placenta Antibodies  >1 publications with NR2E1 and Placenta
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000