Glycine Transporter-1 (slc6a9) Antibody – Goat Polyclonal

The glycine transporter belongs to a family of Na/Cl-dependent neurotransmitter transporters, predicted to contain as many as 12 transmembrane domains. Glycine receptor exists in 2 forms - GLYT1 and GLYT2. Form 1 has three other known isoforms (GLYT1a, GLYT1b, and GLYT1c) which may be produced by alternative spicing or promoter usage. Rodent Glyt1a and Glyt1b differ only by 10 amino acid at the N-terminus and expressed from the same gene. Although, the N-terminal part of mouse and rat GLYT1a is identical in mouse and rat, the N-terminus of GLYT1b are significantly different in these two species. The GLYT1c subtype has only been reported in humans. GLYT1a is expressed in CNS and peripheral organs. GLYT1b is localized in the CNS. Both neuron and Glial cells have GLYT1. More recent studies indicate that GLYt1b may not be brain specific. Immunolocalization studies on GLYT2 suggest that GLYT2 is responsible for terminating the neurotransmission at the strychnine synapses.

• 1. Kim KM et al (1994) Mol. Pharmacol. 45, 608; Smith KE et al (1992) Neuron 8, 927; Guatella J et al (1992) PNAS 89, 7189; Liu KR et al (1992) FEBS Lett. 305, 110; Jursky F et al (1996) J Neurochem. 67, 336

Small volumes of anti-slc6a9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS616708 is an antibody targeting slc6a9. Also known as Anti - Glycine Transporter-1 (GLYT1). Reactive in Human, Rat. Host: Goat
Source: Rat.