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BMP2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6167286

The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq] More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
BMP2, Monoclonal Antibody
Full Product Name
BMP2 (Bone Morphogenetic Protein 2, BMP2A) (APC)
Product Gene Name
anti-BMP2 antibody
Product Synonym Names
Bone Morphogenetic Protein 2; BMP2A
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
3G7
Host
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified
Specificity
Recognizes BMP2.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
44,702 Da
OMIM
112261
3D Structure
ModBase 3D Structure for P12643
Immunogen
BMP2 (NP_001191, 283aa-396aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Conjugate
APC

Product Categories/Family for anti-BMP2 antibody

Antibodies; Growth Factors; Cytokines
Applications Tested/Suitable for anti-BMP2 antibody
ELISA (EIA)
Application Notes for anti-BMP2 antibody
Applications are based on unconjugated antibody.

Testing Data of anti-BMP2 antibody

Detection limit for recombinant GST tagged BMP2 is 0.3 ng/ml as a capture antibody.
Mouse Anti-BMP2 Monoclonal Antibody – Cat# MBS6167286

Product References and Citations for anti-BMP2 antibody

1. Immobilization of Murine Anti-BMP-2 Monoclonal Antibody on Various Biomaterials for Bone Tissue Engineering.Ansari S, Freire MO, Pang EK, Abdelhamid AI, Almohaimeed M, Zadeh HH.Biomed Res Int. 2014;2014:940860. 2.Functionalization of scaffolds with chimeric anti-BMP-2 monoclonal antibodies for osseous regeneration.Ansari S, Moshaverinia A, Pi SH, Han A, Abdelhamid AI, Zadeh HHBiomaterials. 2013 Dec;34(38):10191-8. doi: 10.1016/j.biomaterials.2013.08.069. Epub 2013 Sep 19. 3. Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering. Moshaverinia A, Ansari S, Chen C, Xu X, Akiyama K, Snead ML, Zadeh HH, Shi SBiomaterials. 2013 Sep;34(28):6572-9. doi: 10.1016/j.biomaterials.2013.05.048. Epub 2013 Jun 14. 4.The early events in the healing process of Antibody Mediated Osseous Regeneration (AMOR).Freire MO, Kook JK, Kim HK, Nguyen A, Zadeh HH.Tissue Eng Part A. 2012 Nov 29. 5. Antibody-mediated osseous regeneration: a novel strategy for bioengineering bone by immobilized anti-bone morphogenetic protein-2 antibodies.Freire MO, You HK, Kook JK, Choi JH, Zadeh HH.Tissue Eng Part A. 2011 Dec;17(23-24):2911-8. Epub 2011 Aug 26.

Other Notes

Small volumes of anti-BMP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP2 purchase

MBS6167286 is an antibody targeting BMP2. Also known as BMP2 (Bone Morphogenetic Protein 2, BMP2A) (APC). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP2. It may not necessarily be applicable to this product.

NCBI GI #
4557369
NCBI GeneID
650
NCBI Accession #
NP_001191
UniProt Primary Accession #
P12643
UniProt Related Accession #
P12643
GenBank Nucleotide #
NM_001200.3
NCBI Official Full Name
bone morphogenetic protein 2 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 2
NCBI Official Symbol
BMP2
NCBI Official Synonym Symbols
BDA2; BMP2A
UniProt Protein Name
Bone morphogenetic protein 2
UniProt Synonym Protein Names
Bone morphogenetic protein 2A; BMP-2A
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP2
UniProt Synonym Gene Names
BMP2A; BMP-2; BMP-2A
UniProt Entry Name
BMP2_HUMAN
NCBI Protein Information
bone morphogenetic protein 2

NCBI Summary for BMP2

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
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UniProt Comments for BMP2

Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
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Research Articles on BMP2

1. BMP2-transduced BMSCs can maintain the chondrocyte-like phenotype in PRP gel in vitro, and the combined use of these two agents can significantly promote repair of the degenerated discs in vivo

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BMP2 antibody

 Reference Product  PubMed Publications
 BMPR2 antibody  >207 publications with BMP2 and BMPR2
 BMPR1A antibody  >180 publications with BMP2 and BMPR1A
 SMAD4 antibody  >96 publications with BMP2 and SMAD4
 BMPR1B antibody  >60 publications with BMP2 and BMPR1B
 SMAD7 antibody  >34 publications with BMP2 and SMAD7
 NOG antibody  >11 publications with BMP2 and NOG
 ACVR2B antibody  >9 publications with BMP2 and ACVR2B
 GREM2 antibody  >8 publications with BMP2 and GREM2
 CHRD antibody  >3 publications with BMP2 and CHRD
 SOSTDC1 antibody  >2 publications with BMP2 and SOSTDC1

Pathways associated with anti-BMP2 antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP2-WNT4-FOXO1 Pathway In Human Primary Endometrial Stromal Cell Differentiation antibodies  BMP2-WNT4-FOXO1 Pathway In Human Primary Endometrial Stromal Cell Differentiation Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Bone Morphogenic Protein (BMP) Signalling And Regulation Pathway antibodies  Bone Morphogenic Protein (BMP) Signalling And Regulation Pathway Diagram
 Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway antibodies  Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with anti-BMP2 antibody

 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >571 publications with BMP2 and Bone Diseases
 Necrosis Antibodies  >113 publications with BMP2 and Necrosis
 Inflammation Antibodies  >93 publications with BMP2 and Inflammation
 Pain Antibodies  >46 publications with BMP2 and Pain
 Hypertrophy Antibodies  >45 publications with BMP2 and Hypertrophy
 Hypertension Antibodies  >44 publications with BMP2 and Hypertension
 Fibrosis Antibodies  >34 publications with BMP2 and Fibrosis
 Breast Neoplasms Antibodies  >33 publications with BMP2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >32 publications with BMP2 and Adenocarcinoma
 Kidney Diseases Antibodies  >32 publications with BMP2 and Kidney Diseases

Organs/Tissues associated with anti-BMP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >4206 publications with BMP2 and Bone
 Connective Tissue Antibodies  >649 publications with BMP2 and Connective Tissue
 Embryonic Tissue Antibodies  >456 publications with BMP2 and Embryonic Tissue
 Heart Antibodies  >192 publications with BMP2 and Heart
 Brain Antibodies  >163 publications with BMP2 and Brain
 Kidney Antibodies  >95 publications with BMP2 and Kidney
 Lung Antibodies  >83 publications with BMP2 and Lung
 Liver Antibodies  >70 publications with BMP2 and Liver
 Eye Antibodies  >63 publications with BMP2 and Eye
 Uterus Antibodies  >30 publications with BMP2 and Uterus
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