Tamm-Horsfall Glycoprotein Antibody – Sheep Polyclonal

Tamm-Horsfall glycoprotein (Uromucoid, THgp, Uromodulin, UMOD), which is synthesized by renal tubular cells, is the most abundant protein in normal human urine. Although its physiological function remains unclear, it has been proposed that Uromucoid, THgp, Uromodulin, UMOD may act as a defence factor against urinary tract infections by inhibiting the binding of S- and P-fimbriated Escherichia coli to renal epithelial cells. Because Uromucoid, THgp, Uromodulin, UMOD-related proteins are also found in the superficial layers of the oral mucosa, Uromucoid, THgp, Uromodulin, UMOD may interfere with the cytoadherence of pathogenic bacteria that colonize mucosal surfaces other than those of the urogenital tract. It has been shown that Uromucoid, THgp, Uromodulin, UMOD binds to virulent Bordetella pertussis and reduces its adherence to both renal and pulmonary epithelial cells. This cytoadherence inhibitory effect was not observed with a B. pertussis mutant lacking the pertussis toxin (PTX) operon, and was dependent on the direct interaction of Uromucoid, THgp, Uromodulin, UMOD with the S2 subunit within the PTX B oligomer. It has also been shown that the glycosylation moiety of Uromucoid, THgp, Uromodulin, UMOD is crucial for its binding to PTX. The Uromucoid, THgp, Uromodulin, UMOD-PTX interaction was exploited to develop an affinity chromatography method that allows a one-step purification of active PTX. These observations suggest that besides its anti-adherence activity, Uromucoid, THgp, Uromodulin, UMOD may also trap toxins produced by pathogenic bacteria that colonize mucosal surfaces.

Small volumes of anti-Tamm-Horsfall Glycoprotein antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS616732 is an antibody targeting Tamm-Horsfall Glycoprotein. Also known as Tamm-Horsfall Glycoprotein (Uromucoid, THgp, THP, Uromodulin, UMOD) (Glycerol Free). Reactive in Human. Host: Sheep.