Goat Anti-KLRK1 Polyclonal Antibody – Cat# MBS616765

KLRK1 Antibody – Goat Polyclonal

Name: KLRK1 Antibody; Polyclonal; Goat; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS616765
Price: 835 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS616765

MBS616765 is an antibody targeting KLRK1. Also known as KLRK1 (KLRK1, killer cell lectin-like receptor subfamily K, member 1, HGNC:18788, D12S2489E, KLR, NKG2-D, NKG2D, NK cell receptor D, NKG2-D type II integral membrane protein). Reactive in Human, Mouse,… More details

$835 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KLRK1, Polyclonal Antibody

Full Product Name

KLRK1 (KLRK1, killer cell lectin-like receptor subfamily K, member 1, HGNC:18788, D12S2489E, KLR, NKG2-D, NKG2D, NK cell receptor D, NKG2-D type II integral membrane protein)

Product Gene Name

anti-KLRK1 antibody

Product Synonym Names

Anti -KLRK1 (KLRK1, killer cell lectin-like receptor subfamily K, member 1, HGNC:18788, D12S2489E, KLR, NKG2-D, NKG2D, NK cell receptor D, NKG2-D type II integral membrane protein)

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human, Mouse, Rat

Form/Format

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes Human, Mouse, Rat KLRK1/NKG2D

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

25,274 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (10524952..10542640, complement). Location: 12p13.2-p12.3

OMIM

611817

3D Structure

ModBase 3D Structure for P26718

Immunogen

C-KVYSKEDQDLLK, internal region

Product Categories/Family for anti-KLRK1 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-KLRK1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-KLRK1 antibody

Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Approx 35kD band observed in Human Lymph Node and Human Spleen lysates (calculated MW of 25.3kD according to NP_031386.1). The observed molecular weight is explained by glycosylation (Han et al, Blood. 2004 Nov 1;104(9):2858-66. Epub 2004 Jul 6; PMID: 15238421). Recommended concentration: 0.1-0.3ug/ml., Staining (0.3ug/ml) of Human Spleen lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Optimal dilutions to be determined by the researcher.

Other Notes

Small volumes of anti-KLRK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLRK1. It may not necessarily be applicable to this product.

NCBI GI #

24980985

NCBI GeneID

22914

UniProt Primary Accession #

P26718

UniProt Secondary Accession #

Q9NR41; A8K7K5; A8K7P4

UniProt Related Accession #

P26718; Q1HEA1

NCBI Official Full Name

Killer cell lectin-like receptor subfamily K, member 1

NCBI Official Synonym Full Names

killer cell lectin-like receptor subfamily K, member 1

NCBI Official Symbol

KLRK1

NCBI Official Synonym Symbols

KLR; CD314; NKG2D; NKG2-D; FLJ17759; FLJ75772; D12S2489E

UniProt Protein Name

NKG2-D type II integral membrane protein

UniProt Synonym Protein Names

Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor

Protein Family

NKG2-D type II integral membrane protein

UniProt Gene Name

KLRK1

UniProt Synonym Gene Names

D12S2489E; NKG2D

UniProt Entry Name

NKG2D_HUMAN

NCBI Protein Information

NKG2-D type II integral membrane protein; NK cell receptor D; OTTHUMP00000239062; OTTHUMP00000239064; NKG2-D-activating NK receptor

NCBI Summary for KLRK1

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq]

UniProt Comments for KLRK1

KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: cell surface; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; receptor activity; carbohydrate binding

Biological Process: regulation of immune response; T cell costimulation; innate immune response; natural killer cell activation; signal transduction; cell differentiation; positive regulation of natural killer cell mediated cytotoxicity

Research Articles on KLRK1

1. down-regulation of NKG2D by EBV-induced IDO metabolite provides a potential mechanism by which EBV escapes NKG2D-mediated attack by immune cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLRK1 antibody

Reference Product	PubMed Publications
ULBP3 antibody	>35 publications with KLRK1 and ULBP3
TYROBP antibody	>11 publications with KLRK1 and TYROBP
RAET1E antibody	>11 publications with KLRK1 and RAET1E
RAET1G antibody	>9 publications with KLRK1 and RAET1G
HLA-B antibody	>3 publications with KLRK1 and HLA-B

Pathways associated with anti-KLRK1 antibody

Products by Pathway	Pathway Diagram
Adaptive Immunity Signaling Pathway antibodies	Adaptive Immunity Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Natural Killer Cell Mediated Cytotoxicity Pathway antibodies	Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Natural Killer Cell Mediated Cytotoxicity Pathway antibodies	Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Organs/Tissues associated with anti-KLRK1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>511 publications with KLRK1 and Blood
Liver Antibodies	>29 publications with KLRK1 and Liver
Lung Antibodies	>23 publications with KLRK1 and Lung
Skin Antibodies	>20 publications with KLRK1 and Skin
Spleen Antibodies	>16 publications with KLRK1 and Spleen
Lymph Node Antibodies	>14 publications with KLRK1 and Lymph Node
Lymph Antibodies	>14 publications with KLRK1 and Lymph
Brain Antibodies	>14 publications with KLRK1 and Brain
Kidney Antibodies	>13 publications with KLRK1 and Kidney
Placenta Antibodies	>5 publications with KLRK1 and Placenta