SP100 Antibody – Mouse Monoclonal

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

SP100: May play a role in the control of gene expression. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: nucleoplasm; PML body; Mre11 complex; cytoplasm; nucleolus; nucleus

Molecular Function: identical protein binding; protein domain specific binding; protein binding; protein homodimerization activity; DNA binding; transcription coactivator activity; chromatin binding; kinase binding; transcription factor binding; transcription corepressor activity

Biological Process: retinoic acid receptor signaling pathway; negative regulation of protein export from nucleus; response to retinoic acid; transcription, DNA-dependent; viral reproduction; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; negative regulation of cell motility; negative regulation of transcription from RNA polymerase II promoter; regulation of angiogenesis; negative regulation of DNA binding; chromatin remodeling; negative regulation of viral transcription; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; response to cytokine stimulus; positive regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; telomere maintenance