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Glutamate Transporter, Glial (SLC1A2) Antibody – Guinea Pig Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS616849

Glutamate transporters (GluT) function to remove L-glutamate (Glu), the primary excitatory neurotransmitter in the mammalian central nervous system (CNS), from the synaptic cleft. By clearing the synapse in this manner Glu can be recycled for later use, the… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Glutamate Transporter, Glial (Slc1a2), Polyclonal Antibody
Full Product Name
Guinea pig Anti-Glutamate Transporter, Glial
Product Gene Name
anti-Slc1a2 antibody
Product Synonym Names
SLC1A2; EAAT2; GLT1; Excitatory Amino Acid Transporter 2; Solute Carrier Family 1 Member 2
Clonality
Polyclonal
Isotype
IgG
Host
Host: Guinea pig; Source: Rat
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid, 0.05% sodium azide
Purity/Purification
Serum
Specificity
Recognizes rat Glial Glutamate Transporter GLT-1 (EAAT2). Species Crossreactivity: human and mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
62,030 Da
Chromosome Location
Chromosome: 2; NC_000068.6 (102498840..102630941). Location: 2 E2; 2 54.0 cM
3D Structure
ModBase 3D Structure for P31596
Immunogen
Synthetic peptide corresponding to the C-terminal of rat GLT-1

Product Categories/Family for anti-Slc1a2 antibody

Antibodies; Abs to Transport Proteins
Applications Tested/Suitable for anti-Slc1a2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-Slc1a2 antibody
Immunohistochemistry (Paraffin): 1:1000-1:4000 Immunohistochemistry: 1:5000-10,000 Western Blot: 1:500 detected GLT-1 on 10ug of mouse brain lysates Optimal dilution to be determined by researcher

Testing Data of anti-Slc1a2 antibody

Staining of rat trigeminal motor nucleus using MBS616849
Guinea Pig Anti-SLC1A2 Polyclonal Antibody – Cat# MBS616849

Testing Data of anti-Slc1a2 antibody

Staining of rat striatum using MBS616849.
Guinea Pig Anti-SLC1A2 Polyclonal Antibody, Testing Data – Cat# MBS616849

Other Notes

Small volumes of anti-Slc1a2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Slc1a2 purchase

MBS616849 is an antibody targeting Slc1a2. Also known as Guinea pig Anti-Glutamate Transporter, Glial. Reactive in Human, Mouse, Rat. Host: Guinea pig; Source: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for Slc1a2. It may not necessarily be applicable to this product.

NCBI GeneID
20511
UniProt Primary Accession #
P31596
GenBank Nucleotide #
NM_004171.3
NCBI Official Full Name
glutamate transporter
NCBI Official Synonym Full Names
solute carrier family 1 (glial high affinity glutamate transporter), member 2
NCBI Official Symbol
Slc1a2
NCBI Official Synonym Symbols
GLT1; Eaat2; GLT-1; MGLT1; AI159670; 1700091C19Rik; 2900019G14Rik
UniProt Protein Name
Excitatory amino acid transporter 2
UniProt Synonym Protein Names
GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2
Protein Family
Excitatory amino acid transporter
UniProt Gene Name
Slc1a2
UniProt Synonym Gene Names
Eaat2; Glt1
UniProt Entry Name
EAA2_MOUSE
NCBI Protein Information
excitatory amino acid transporter 2; OTTMUSP00000015765; OTTMUSP00000015766; OTTMUSP00000015767; OTTMUSP00000015768; solute carrier family 1 member 2; solute carrier family 1, member 2; glial high affinity glutamate transporter; sodium-dependent glutamate/aspartate transporter 2

UniProt Comments for Slc1a2

GLT1: an integral membrane protein belonging to the sodium:dicarboxylate (SDF) symporter family. Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by co-transporting sodium.

Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter

Cellular Component: presynaptic membrane; neuron projection; membrane; integral to plasma membrane; axon; integral to membrane; dendritic spine; plasma membrane; synapse; axolemma; dendritic shaft

Molecular Function: symporter activity; high-affinity glutamate transmembrane transporter activity; glutamate:sodium symporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity

Biological Process: response to drug; response to light stimulus; nervous system development; L-glutamate transport; multicellular organism growth; multicellular organismal aging; response to amino acid stimulus; visual behavior; L-glutamate import; positive regulation of glucose import; telencephalon development; dicarboxylic acid transport; transport; adult behavior; cellular response to extracellular stimulus; response to wounding
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Research Articles on Slc1a2

1. GLT1 is a new player in glutamate homeostasis and signaling in the islet of Langerhans; beta-cells critically depend on its activity to control extracellular glutamate levels and cellular integrity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Slc1a2 antibody

 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway antibodies  Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Neurotransmitter Uptake And Metabolism In Glial Cells Pathway antibodies  Neurotransmitter Uptake And Metabolism In Glial Cells Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Synaptic Transmission Pathway antibodies  Synaptic Transmission Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-Slc1a2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >45 publications with Slc1a2 and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >35 publications with Slc1a2 and Central Nervous System Diseases
 Mental Disorders Antibodies  >22 publications with Slc1a2 and Mental Disorders
 Death Antibodies  >21 publications with Slc1a2 and Death
 Neoplasms Antibodies  >11 publications with Slc1a2 and Neoplasms
 Cardiovascular Diseases Antibodies  >10 publications with Slc1a2 and Cardiovascular Diseases
 Neurodegenerative Diseases Antibodies  >9 publications with Slc1a2 and Neurodegenerative Diseases
 Schizophrenia Antibodies  >9 publications with Slc1a2 and Schizophrenia
 Glioma Antibodies  >7 publications with Slc1a2 and Glioma
 Dementia Antibodies  >6 publications with Slc1a2 and Dementia

Organs/Tissues associated with anti-Slc1a2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >82 publications with Slc1a2 and Brain
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