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CYP46A1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6169418

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CYP46A1, Monoclonal Antibody
Full Product Name
CYP46A1 (Cytochrome P450, Family 46, Subfamily A, Polypeptide 1, CP46, CYP46) (APC)
Product Gene Name
Product Synonym Names
Cytochrome P450; Family 46; Subfamily A; Polypeptide 1; CP46; CYP46
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
2B5
Host
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified
Specificity
Recognizes CYP46A1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
38,315 Da
OMIM
604087
3D Structure
ModBase 3D Structure for Q9Y6A2
Immunogen
CYP46A1 (NP_006659, 201aa-300aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF
Conjugate
APC

Product Categories/Family for anti-CYP46A1 antibody

Applications Tested/Suitable for anti-CYP46A1 antibody
Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CYP46A1 antibody
Applications are based on unconjugated antibody.

Testing Data of anti-CYP46A1 antibody

Detection limit for recombinant GST tagged CYP46A1 is 0.03 ng/ml as a capture antibody.
Mouse Anti-CYP46A1 Monoclonal Antibody – Cat# MBS6169418

Immunoprecipitation (IP) of anti-CYP46A1 antibody

Immunoprecipitation of CYP46A1 transfected lysate using anti-CYP46A1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with CYP46A1 MaxPab rabbit polyclonal antibody.
Mouse Anti-CYP46A1 Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS6169418

Other Notes

Small volumes of anti-CYP46A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYP46A1 purchase

MBS6169418 is an antibody targeting CYP46A1. Also known as CYP46A1 (Cytochrome P450, Family 46, Subfamily A, Polypeptide 1, CP46, CYP46) (APC). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP46A1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cholesterol 24-hydroxylase
NCBI Official Synonym Full Names
cytochrome P450, family 46, subfamily A, polypeptide 1
NCBI Official Symbol
CYP46A1
NCBI Official Synonym Symbols
CP46; CYP46
UniProt Protein Name
Cholesterol 24-hydroxylase
UniProt Synonym Protein Names
Cytochrome P450 46A1
UniProt Gene Name
CYP46A1
UniProt Synonym Gene Names
CYP46; CH24H
UniProt Entry Name
CP46A_HUMAN
NCBI Protein Information
cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)

UniProt Comments for CYP46A1

CYP46A1: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.13.98; Lipid Metabolism - primary bile acid biosynthesis; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: iron ion binding; cholesterol 24-hydroxylase activity; heme binding; steroid hydroxylase activity

Biological Process: nervous system development; bile acid biosynthetic process; bile acid metabolic process; xenobiotic metabolic process; cholesterol catabolic process; sterol metabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CYP46A1 antibody

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