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EHD2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6169428

This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EHD2, Monoclonal Antibody
Full Product Name
EHD2 (EH-Domain Containing 2, FLJ96617, PAST2) (APC)
Product Gene Name
anti-EHD2 antibody
Product Synonym Names
EH-Domain Containing 2; FLJ96617; PAST2
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
1F1
Host
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography
Specificity
Recognizes human EHD2.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
605890
3D Structure
ModBase 3D Structure for Q9NZN4
Immunogen
Partial recombinant protein corresponding to aa365-427 from EHD2 (NP_055416) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
AHDFTKFHSLKPKLLEALDEMLTHDIAKLMPLLRQEELESTEVGVQGGAFEGTHMGPFVERGP
Conjugate
APC

Product Categories/Family for anti-EHD2 antibody

Antibodies; Binding Proteins
Applications Tested/Suitable for anti-EHD2 antibody
Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-EHD2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-EHD2 antibody

Western Blot analysis of EHD2 expression using in HeLa.
Mouse Anti-EHD2 Monoclonal Antibody – Cat# MBS6169428

Testing Data of anti-EHD2 antibody

Detection limit for recombinant GST tagged EHD2 is 0.1 ng/ml as a capture antibody.
Mouse Anti-EHD2 Monoclonal Antibody, Testing Data – Cat# MBS6169428

Immunofluorescence (IF) of anti-EHD2 antibody

Immunofluorescence of (10ug/ml) on HeLa cell.
Mouse Anti-EHD2 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS6169428

Immunofluorescence (IF) of anti-EHD2 antibody

Immunofluorescence of (10ug/ml) on HeLa cell.
Mouse Anti-EHD2 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS6169428

Other Notes

Small volumes of anti-EHD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EHD2 purchase

MBS6169428 is an antibody targeting EHD2. Also known as EHD2 (EH-Domain Containing 2, FLJ96617, PAST2) (APC). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for EHD2. It may not necessarily be applicable to this product.

NCBI GI #
21361462
NCBI GeneID
30846
NCBI Accession #
NP_055416
UniProt Primary Accession #
Q9NZN4
UniProt Related Accession #
Q9NZN4
GenBank Nucleotide #
NP_055416.2
NCBI Official Full Name
EH domain-containing protein 2
NCBI Official Synonym Full Names
EH domain containing 2
NCBI Official Symbol
EHD2
NCBI Official Synonym Symbols
PAST2
UniProt Protein Name
EH domain-containing protein 2
UniProt Synonym Protein Names
PAST homolog 2
Protein Family
EH domain-containing protein
UniProt Gene Name
EHD2
UniProt Synonym Gene Names
PAST2
UniProt Entry Name
EHD2_HUMAN
NCBI Protein Information
EH domain-containing protein 2

UniProt Comments for EHD2

EHD2: Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: recycling endosome membrane; perinuclear region of cytoplasm; plasma membrane; endosome membrane; caveola; nucleus

Molecular Function: protein domain specific binding; protein binding; nucleic acid binding; GTP binding; hydrolase activity; calcium ion binding; ATP binding

Biological Process: metabolic process; endocytosis; cortical actin cytoskeleton organization and biogenesis; endocytic recycling; blood coagulation
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Research Articles on EHD2

1. EHD2-controlled caveolar dynamics orchestrates the activity and regulation of eNOS/nitric oxide and Ca2+ channel localization at the plasma membrane.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EHD2 antibody

 Reference Product  PubMed Publications
 EHD1 antibody  >23 publications with EHD2 and EHD1
 EHD3 antibody  >12 publications with EHD2 and EHD3
 PACSIN2 antibody  >5 publications with EHD2 and PACSIN2
 EHBP1 antibody  >5 publications with EHD2 and EHBP1
 SLC2A4 antibody  >2 publications with EHD2 and SLC2A4
 CAV1 antibody  >1 publications with EHD2 and CAV1
 FER1L5 antibody  >1 publications with EHD2 and FER1L5

Pathways associated with anti-EHD2 antibody

 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram

Diseases associated with anti-EHD2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with EHD2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with EHD2 and Disease Models, Animal
 Brain Diseases Antibodies  >1 publications with EHD2 and Brain Diseases
 Skin Diseases Antibodies  >1 publications with EHD2 and Skin Diseases
 Breast Neoplasms Antibodies  >1 publications with EHD2 and Breast Neoplasms
 Ovarian Diseases Antibodies  >1 publications with EHD2 and Ovarian Diseases
 Myocardial Infarction Antibodies  >1 publications with EHD2 and Myocardial Infarction
 Ovarian Neoplasms Antibodies  >1 publications with EHD2 and Ovarian Neoplasms

Organs/Tissues associated with anti-EHD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >9 publications with EHD2 and Muscle
 Brain Antibodies  >5 publications with EHD2 and Brain
 Vascular Antibodies  >2 publications with EHD2 and Vascular
 Heart Antibodies  >2 publications with EHD2 and Heart
 Connective Tissue Antibodies  >2 publications with EHD2 and Connective Tissue
 Adipose Tissue Antibodies  >2 publications with EHD2 and Adipose Tissue
 Liver Antibodies  >1 publications with EHD2 and Liver
 Stomach Antibodies  >1 publications with EHD2 and Stomach
 Pancreas Antibodies  >1 publications with EHD2 and Pancreas
 Kidney Antibodies  >1 publications with EHD2 and Kidney
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