Rabbit Anti-SLC1A6 Polyclonal Antibody – Cat# MBS616982

Glutamate Transporter EAAT4 (SLC1A6) Antibody – Rabbit Polyclonal

Name: SLC1A6 Antibody; Polyclonal; Rabbit; Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS616982
Price: 980 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS616982

Glutamate is the main excitatory neurotransmitter in the brain. To date five glutamate Transporters have been cloned: GLAST (EAAT1), GLT1 (EAAT2), EAAC1 (EAAT3), EAAT4, and EAAT5. These transporters are believed to be critical in reducing potentially toxic… More details

$980 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glutamate Transporter EAAT4 (SLC1A6), Polyclonal Antibody

Full Product Name

Anti - Glutamate Transporter EAAT4 (Excitatory Amino Acid Transporter 4)

Product Gene Name

anti-SLC1A6 antibody

Product Synonym Names

Glutamate Transporter EAAT4 (Excitatory Amino Acid Transporter 4)

Clonality

Polyclonal

Isotype

IgG

Host

Host: Rabbit
Source: Rat

Species Reactivity

Mouse, Rat

Form/Format

Affinity Purified
Supplied as a liquid in PBS, pH 7.4 and 0.1% sodium azide, 40% glycerol.

Purity/Purification

Purified by immunoaffinity chromatography.

Specificity

The peptide was found unique to EAAT4 without significant homology to other glutamate transporters. It is 100% homologous in mouse and 90% in human EAAT4. Antibody crossreactivity in various species is not established.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

61,466 Da

Chromosome Location

Chromosome: 20; NC_006602.2 (50137157..50147431)

3D Structure

ModBase 3D Structure for Q9N1R2

Immunogen

A 21AA synthetic peptide near the cytoplasmic, C-terminus of rat EAAT4 (1) was synthesized, conjugated to KLH.

Product Categories/Family for anti-SLC1A6 antibody

Abs to Proteins

Applications Tested/Suitable for anti-SLC1A6 antibody

ELISA, Western Blot

Application Notes for anti-SLC1A6 antibody

Suitable for use in ELISA, Western Blotting. Other applications not tested.
Dilution: Western Blot: 1:1000-1:5000 for neat serum and 1-10ug/ml for affinity pure antibody using Chemiluminescence technique (2). EAAT4 monomers in freshly made rat brain extracts appeared as fuzzy ~65kD protein (2). High MW bands may be see after oxidation (2).
ELISA: 1:10,000-50,000 for neat serum and 0.5-1ug/ml for affinity pure. Control peptide can be used to coat ELISA plates at 1ug/ml.
Optimal dilutions to be determined by the researcher.
Control peptide, because of its low MW (<3kD), is not suitable for Western. It is recommed for ELISA, dot blot, or for antibody blocking experiments (use 5-10ug of control peptide per 1ug of affinity pure IgG or 1ul of antiserum) to demonstrate antibody specificity.

Product References and Citations for anti-SLC1A6 antibody

• 1. Lin C et al (1997) gene accession # g3023680; Maeno-Hikichi Y et al (1997) Brain Res. Mol. Brain. Res. 48, 176-180; Fairbanks WA et a (1995) Nature 375, 599-6032. Dehnes Y et al (1998) J Neurosci. 18, 3606-3619; Furuta A et al (1997) J Neurosci. 17, 8363-8375.

Other Notes

Small volumes of anti-SLC1A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC1A6 purchase

MBS616982 is an antibody targeting SLC1A6. Also known as Anti - Glutamate Transporter EAAT4 (Excitatory Amino Acid Transporter 4). Reactive in Mouse, Rat. Host: Rabbit
Source: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC1A6. It may not necessarily be applicable to this product.

NCBI GI #

6978311

NCBI GeneID

403749

UniProt Primary Accession #

Q9N1R2

UniProt Related Accession #

Q9N1R2

NCBI Official Full Name

glutamate transporter

NCBI Official Symbol

SLC1A6

NCBI Official Synonym Symbols

EAAT4

UniProt Protein Name

Excitatory amino acid transporter 4

UniProt Synonym Protein Names

Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6

Protein Family

Excitatory amino acid transporter

UniProt Gene Name

SLC1A6

UniProt Synonym Gene Names

EAAT4

UniProt Entry Name

EAA4_CANFA

NCBI Protein Information

excitatory amino acid transporter 4; glutamate transporter; solute carrier family 1 member 6; sodium-dependent glutamate/aspartate transporter

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SLC1A6 antibody

Products by Pathway	Pathway Diagram
Glutamate Neurotransmitter Release Cycle Pathway antibodies	Glutamate Neurotransmitter Release Cycle Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Neurotransmitter Release Cycle Pathway antibodies	Neurotransmitter Release Cycle Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Synaptic Transmission Pathway antibodies	Synaptic Transmission Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Transmission Across Chemical Synapses Pathway antibodies	Transmission Across Chemical Synapses Pathway Diagram
Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies	Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC1A6 antibody

Disease Name	Pubmed Publications
Drug Toxicity Antibodies	>1 publications with SLC1A6 and Drug Toxicity
Hemorrhage Antibodies	>1 publications with SLC1A6 and Hemorrhage
Wasting Syndrome Antibodies	>1 publications with SLC1A6 and Wasting Syndrome
Inflammation Antibodies	>1 publications with SLC1A6 and Inflammation

Organs/Tissues associated with anti-SLC1A6 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>51 publications with SLC1A6 and Brain