EIF2AK3 Antibody – Mouse Monoclonal

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

MLK2: a TKL kinase of the MLK family. A dual leucine zipper kinase. Phosphorylates and activates JNK and SEK1. Interacts with PAK and NCK. May be involved in nerve growth factor-induced neuronal apoptosis.

Protein type: Kinase, protein; EC 2.7.11.25; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; JUN kinase kinase kinase activity; protein homodimerization activity; bHLH transcription factor binding; transcription corepressor activity; ATP binding; protein kinase activity

Biological Process: positive regulation of JNK activity; smoothened signaling pathway; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; negative regulation of transcription factor activity; peptidyl-threonine phosphorylation; positive regulation of JNK cascade; signal transduction; activation of JNK activity; peptidyl-serine phosphorylation; JNK cascade; negative regulation of transcription, DNA-dependent; activation of JNKK activity