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LASS3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6170243

MBS6170243 is an antibody targeting LASS3. Also known as LASS3 (LAG1 Homolog, Ceramide Synthase 3, CerS3, MGC27091) (APC). Host: Mouse. Mouse monoclonal antibody raised against a partial recombinant LASS3. More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LASS3, Monoclonal Antibody
Full Product Name
LASS3 (LAG1 Homolog, Ceramide Synthase 3, CerS3, MGC27091) (APC)
Product Gene Name
anti-LASS3 antibody
Product Synonym Names
LAG1 Homolog; Ceramide Synthase 3; CerS3; MGC27091
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
6C12
Host
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified
Specificity
Recognizes LASS3.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
46kDa
3D Structure
ModBase 3D Structure for Q8IU89
Immunogen
LASS3 (NP_849164, 57aa-134aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
EKFVASPLAKSFGIKETVRKVTPNTVLENFFKHSTRQPLQTDIYGLAKKCNLTERQVERWFRSRRNQERPSRLKKFQE
Conjugate
APC

Product Categories/Family for anti-LASS3 antibody

Antibodies; Enzymes; Synthase
Applications Tested/Suitable for anti-LASS3 antibody
Western Blot (WB)
Application Notes for anti-LASS3 antibody
Applications are based on unconjugated antibody.

Testing Data of anti-LASS3 antibody

Detection limit for recombinant GST tagged LASS3 is 0.1 ng/ml as a capture antibody.
Mouse Anti-LASS3 Monoclonal Antibody – Cat# MBS6170243

Western Blot (WB) of anti-LASS3 antibody

Western Blot analysis of LASS3 expression in transfected 293T cell line by LASS3 monoclonal antibody (M02), clone 6C12.

Lane 1: LASS3 transfected lysate (Predicted MW: 42.13 KDa).
Lane 2: Non-transfected lysate.
Mouse Anti-LASS3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6170243

Western Blot (WB) of anti-LASS3 antibody

LASS3 monoclonal antibody (M02), clone 6C12. Western Blot analysis of LASS3 expression in MCF-7.
Mouse Anti-LASS3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6170243

Western Blot (WB) of anti-LASS3 antibody

LASS3 monoclonal antibody (M02), clone 6C12. Western Blot analysis of LASS3 expression in Raw 264.7.
Mouse Anti-LASS3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6170243

Western Blot (WB) of anti-LASS3 antibody

LASS3 monoclonal antibody (M02), clone 6C12. Western Blot analysis of LASS3 expression in PC-12.
Mouse Anti-LASS3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6170243

Other Notes

Small volumes of anti-LASS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LASS3. It may not necessarily be applicable to this product.

NCBI GI #
116235446
NCBI GeneID
204219
NCBI Accession #
NP_849164
UniProt Primary Accession #
Q8IU89
UniProt Related Accession #
Q8IU89
GenBank Nucleotide #
NM_178842
NCBI Official Full Name
ceramide synthase 3 isoform 2
NCBI Official Synonym Full Names
ceramide synthase 3
NCBI Official Symbol
CERS3
NCBI Official Synonym Symbols
ARCI9; LASS3
UniProt Protein Name
Ceramide synthase 3
UniProt Synonym Protein Names
LAG1 longevity assurance homolog 3
UniProt Gene Name
CERS3
UniProt Synonym Gene Names
LASS3; CerS3
UniProt Entry Name
CERS3_HUMAN
NCBI Protein Information
ceramide synthase 3

NCBI Summary for LASS3

This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
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UniProt Comments for LASS3

Function: May be involved in sphingolipid synthesis or its regulation

By similarity.

Subcellular location: Nucleus membrane; Multi-pass membrane protein

Potential.

Sequence similarities: Contains 1 homeobox DNA-binding domain.Contains 1 TLC (TRAM/LAG1/CLN8) domain.

Research Articles on LASS3

1. Novel mutations in CERS3 co-segregated with the ichthyosis phenotype in six Iranian families.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-LASS3 antibody

 Products by Pathway  Pathway Diagram
 Ceramide Biosynthesis Pathway antibodies  Ceramide Biosynthesis Pathway Diagram
 Ceramide Biosynthesis Pathway antibodies  Ceramide Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingosine Biosynthesis Pathway antibodies  Sphingosine Biosynthesis Pathway Diagram

Diseases associated with anti-LASS3 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >1 publications with LASS3 and Death
 Immune System Diseases Antibodies  >1 publications with LASS3 and Immune System Diseases
 Lymphatic Diseases Antibodies  >1 publications with LASS3 and Lymphatic Diseases
 Genital Diseases, Male Antibodies  >1 publications with LASS3 and Genital Diseases, Male
 Eye Abnormalities Antibodies  >1 publications with LASS3 and Eye Abnormalities

Organs/Tissues associated with anti-LASS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >4 publications with LASS3 and Skin
 Testis Antibodies  >3 publications with LASS3 and Testis
 Eye Antibodies  >1 publications with LASS3 and Eye
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