CRX Antibody – Mouse Monoclonal

The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq]

1. From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium. Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot EF, Sahel JA, Monville C, Goureau OProc Natl Acad Sci U S A. 2014 Jun 10;111(23):8518-23. doi: 10.1073/pnas.1324212111. Epub 2014 May 27. 2.Mechanistically Distinct Mouse Models for CRX-Associated Retinopathy. Tran NM, Zhang A, Zhang X, Huecker JB, Hennig AK, Chen SPLoS Genet. 2014 Feb 6;10(2):e1004111. doi: 10.1371/journal.pgen.1004111. eCollection 2014 Feb. 3.The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide.Carr AJ, Vugler AA, Yu L, Semo M, Coffey P, Moss SE, Greenwood J.Mol Vis. 2011;17:1701-15. Epub 2011 Jun 25. 4.Distinct Effects of Hedgehog Signaling on Neuronal Fate Specification and Cell Cycle Progression in the Embryonic Mouse Retina. Sakagami K, Gan L, Yang XJ.J Neurosci. 2009 May 27;29(21):6932-44. 5.BEST1 expression in the retinal pigment epithelium is modulated by OTX family members.Esumi N, Kachi S, Hackler L Jr, Masuda T, Yang Z, Campochiaro PA, Zack DJ.Hum Mol Genet. 2009 Jan 1;18(1):128-41. Epub 2008 Oct 10. 6.Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation.Peng GH, Chen S.Hum Mol Genet. 2007 Oct 15;16(20):3433-52. Epub 2007 Jul 26.

Small volumes of anti-CRX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6170378 is an antibody targeting CRX. Also known as CRX (Cone-rod Homeobox, CORD2, CRD, LCA7, OTX3) (Biotin). Host: Mouse.