Bacillus Anthracis Toxin Receptor 3 Antibody – Rabbit Polyclonal

Anthrax toxin secreted by Bacillus anthracis, consists of three polypeptides: protective antigen (PA, 83kD) lethal factor (LF, 90kD) and oedma factor (OF, 89kD). The two components (OF and LF) of the toxin enzymatically modify substrates within the cytosol of the mammalian cells: The OF is an adenylate cyclase that impairs the host defenses through a variety of mechanisms inhibiting phagocytosis. The LF is a zinc dependent protease that cleaves mitogen activated protein kinase kinase (MAPKK) and causes lysis of macrophages. To intoxicate mammalian cells, the third component of the toxin PA, binds to a ubiquitously expressed cellular receptor, Tumor Endothelium Marker-8 (TEM8). Upon binding to TEM8, PA is cleaved into 20 and 63kDa fragments (PA20 and PA63) by furin or furin-like proteases. PA63 fragment then forms a complex with LF and OF components of toxin leading to internalization and translocation of LF and OF into cytosol of the cells.

• Bradley KA et al (2001) Nature 414, 225-229; liu S and Leppla SH (2002) JBC (in press); Leppla, SH (1982) PNAS 79, 3182; O'Brien J et al (1985) Infect Immun 47, 306; Duesbery, NS et al (1998) Science 280, 734.

Small volumes of anti-Bacillus anthracis Toxin Receptor 3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS617103 is an antibody targeting Bacillus anthracis Toxin Receptor 3. Also known as Anti - Bacillus anthracis Toxin Receptor 3 (Anthrax). Host: Rabbit.