Estrogen Receptor B1, B2 Antibody – Rabbit Polyclonal

Mouse/rat ERb1 gene encodes a protein of 485aa with a calculated size of approx. 54kD (1). Rat ERb1 is highly conserved in the DNA-binding domain (>90% homology) and the C-terminal ligand binding domain (55% homology). The A/B domain, the hinge region and the F-domain are not conserved. Rat ERb1 is primarily expressed in prostate, ovary, lung, bladder, brain, uterus, and testis. Most recently functional variants of ERb1, termed ERb2, have been cloned. ERbb has an additional 18 aa as a results of in-frame mutation within the ligand-binding domain. ERb1 is expressed in ovary, prostate, pituitary, brain, and muscle. Variants of both ERb1 and ERb2 (ERb1d3, ERb2d3) were detected that show deletion of 39 aa in the DNA-binding domain. Both ERb1 and ERb2 specifically bind to ER response element. ERa, b1 and ERb2 have been found to heterodimerize with each other.

• 1. Kuiper GG et al (1996) Proc Natl Acad Sci 93:5925-5930.
• 2. Tremblay, GB et al (1997) Mol. Endocrinol. 11:353-365.
• 3. Mosselman S et al (1996) FEBS Lett. 392:49-53.
• 4. Peterson DN et al (198) Endocrinology 139:1082.
• 5. Maruyama K et al (1998) BBRC 246:142.

Small volumes of anti-Estrogen Receptor b1, b2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS617269 is an antibody targeting Estrogen Receptor b1, b2. Also known as Anti - Estrogen Receptor b1, b2 (ERb1, 2). Reactive in Human. Host: Rabbit
Source: Human.