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VSIG4 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS617290

VSIG4 (V-set and Ig domain-containing protein 4; also Z39Ig) is a 45-50kD macrophage-specific protein that belongs to the B7 family of molecules. Its constitutive expression depresses unwarranted T cell activation. Human VSIG4 is 399 amino acids (aa) in… More details

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Product Overview

Online Datasheet in PDF
Product Name
VSIG4, Polyclonal Antibody
Full Product Name
VSIG4 (V-set and Ig Domain-containing Protein 4, Z39Ig)
Product Gene Name
Product Synonym Names
Anti -VSIG4 (V-set and Ig Domain-containing Protein 4, Z39Ig)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from PBS with 5% trehalose. Reconstitute with 200ul 40-50% glycerol, PBS.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human VSIG4.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
43,987 Da
Chromosome Location
Chromosome: X; NC_000023.10 (65241580..65259967, complement). Location: Xq12-q13.3
OMIM
300353
3D Structure
ModBase 3D Structure for Q9Y279
Immunogen
NS0-derived, recombinant human VSIG4.
Applications Tested/Suitable for anti-VSIG4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-VSIG4 antibody
Dilution: Direct ELISA: 0.5-1ug/mL detection limit for rhVSIG4 ~ 1ng/well
Western Blot: 0.1-0.2ug/mL detection limit for rhVSIG4 ~ 1ng/lane under non-reducing and reducing conditions.

Other Notes

Small volumes of anti-VSIG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VSIG4 purchase

MBS617290 is an antibody targeting VSIG4. Also known as VSIG4 (V-set and Ig Domain-containing Protein 4, Z39Ig). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for VSIG4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
V-set and immunoglobulin domain-containing protein 4 isoform 4
NCBI Official Synonym Full Names
V-set and immunoglobulin domain containing 4
NCBI Official Symbol
VSIG4
NCBI Official Synonym Symbols
CRIg; Z39IG
UniProt Protein Name
V-set and immunoglobulin domain-containing protein 4
UniProt Synonym Protein Names
Protein Z39Ig
UniProt Gene Name
VSIG4
UniProt Synonym Gene Names
CRIg; Z39IG
UniProt Entry Name
VSIG4_HUMAN
NCBI Protein Information
V-set and immunoglobulin domain-containing protein 4; protein Z39Ig; OTTHUMP00000023439; OTTHUMP00000023441; OTTHUMP00000023442; Ig superfamily protein; complement receptor of the immunoglobulin superfamily

NCBI Summary for VSIG4

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq]
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UniProt Comments for VSIG4

VSIG4: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xq12-q13.3

Cellular Component: integral to membrane

Molecular Function: protein binding

Biological Process: negative regulation of T cell proliferation; complement activation, alternative pathway; negative regulation of interleukin-2 production
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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