SGLT-3 Antibody – Rabbit Polyclonal

The kidneys play a major role in the regulation of glucose levels. Kidneys filter approx. 180 g of glucose per day from the blood, and this is mostly reabsorbed back into the blood in the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, Sodium glucoseco transporters (SGLT), in the brush-border membrane and then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). At least 3 members of SGLTs (SGLT1-3) have been cloned and characterized from various species. Individual member of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT1-3 genes code for protein of approx 659-672 residues (calculated size of ~75kD). Both N and C-termini are predicted to be extracellualr. There is approx 60-70% homology between SGLT1-3. SGLTs transport a-methyl-D-glucoside (a-MDG), a non-metabolized model substrate, in Na-dependent manner. SGLT1 does not discriminate a-MDG, glucose, and galactose. SGLT2/3 do not transport D-galactose efficiently.

• 1. Tatabai Nm et al (2001) Toxicol. Appl. Pharamcol. 177, 163-177; Kong CT et al (1993) JBC 268, 1509-1512; Mackenzie B et al (1994) JBC 269, 22488-22491; Dunham I et al (1999) Nature 402, 489-495; Wright E (2001) Am. J. Physiol. Renal Physiol. 280, F10-F18 (review).

Small volumes of anti-SGLT-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS617428 is an antibody targeting SGLT-3. Also known as Anti - SGLT-3 (Sodium Glucose Transporter 3). Reactive in Porcine. Host: Rabbit
Source: Porcine.