Novel Organic Cation Transporter 1 Antibody – Rabbit Polyclonal

Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic cations from the blood by an active process called "renal secretion". Functional studies have identified two distinct categories of organic cation transporters (Octs): a system driven by transmembrane potential difference that governs the influx of cations, whereas the H+-gradient-dependent transport system may mediate the efflux of organic cations. Several multispecific, potential-sensitive transporters (Oct1-3) and H+-dependent transporters (OctN1-3) have been cloned and characterized from various tissues. Oct superfamily of proteins shares high degree of sequence homology, display up to 12 transmembrane domains with cytoplasmic N and C-terminus. A novel transporter termed OctN1, has been cloned and characterized human fetal liver, which carries a nucleotide birding site motif. OctN1 (human 551aa, mouse 55aa) shares ~32% homology with Oct1-3. It is strongly expressed in adult kidney, trachea, bone marrow, and fetal liver, and several tumor cells, but not in adult human liver. OctN1 mediated uptake of TEA in pH dependent manner.

Small volumes of anti-Novel Organic Cation Transporter 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS617546 is an antibody targeting Novel Organic Cation Transporter 1. Also known as Novel Organic Cation Transporter 1 (OctN1). Reactive in Mouse. Host: Rabbit.