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DEGS1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6176293

This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DEGS1, Monoclonal Antibody
Full Product Name
DEGS1 (Degenerative Spermatocyte Homolog 1, lipid Desaturase (Drosophila), DEGS, DES1, Des-1, FADS7, MGC5079, MIG15, MLD) (FITC)
Product Gene Name
Product Synonym Names
Degenerative Spermatocyte Homolog 1; lipid Desaturase (Drosophila); DEGS; DES1; Des-1; FADS7; MGC5079; MIG15; MLD
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
2.0e+9
Host
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).
Purity/Purification
Purified
Specificity
Recognizes DEGS1.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.

FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
38kDa
3D Structure
ModBase 3D Structure for O15121
Immunogen
DEGS1 (NP_003667, 226aa-323aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
SGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDFVMDDTISPYSRMKRHQKGEMVLE
Conjugate
FITC
Applications Tested/Suitable for anti-DEGS1 antibody
ELISA (EIA)
Application Notes for anti-DEGS1 antibody
Applications are based on unconjugated antibody.

Testing Data of anti-DEGS1 antibody

Detection limit for recombinant GST tagged DEGS1 is approximately 0.3ng/ml as a capture antibody.
Mouse Anti-DEGS1 Monoclonal Antibody – Cat# MBS6176293

Other Notes

Small volumes of anti-DEGS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DEGS1 purchase

MBS6176293 is an antibody targeting DEGS1. Also known as DEGS1 (Degenerative Spermatocyte Homolog 1, lipid Desaturase (Drosophila), DEGS, DES1, Des-1, FADS7, MGC5079, MIG15, MLD) (FITC). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DEGS1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sphingolipid delta(4)-desaturase DES1 isoform 1
NCBI Official Synonym Full Names
delta 4-desaturase, sphingolipid 1
NCBI Official Symbol
DEGS1
NCBI Official Synonym Symbols
MLD; DEGS; DES1; Des-1; FADS7; MIG15; DEGS-1
UniProt Protein Name
Sphingolipid delta(4)-desaturase DES1
UniProt Synonym Protein Names
Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Membrane lipid desaturase
UniProt Gene Name
DEGS1
UniProt Synonym Gene Names
DES1; MLD
UniProt Entry Name
DEGS1_HUMAN
NCBI Protein Information
sphingolipid delta(4)-desaturase DES1

NCBI Summary for DEGS1

This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]
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UniProt Comments for DEGS1

Function: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Ref.2

Subcellular location: Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1 Ref.7.

Tissue specificity: Ubiquitous. Ref.1

Post-translational modification: Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels.

Sequence similarities: Belongs to the fatty acid desaturase family. DEGS subfamily.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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