Rabbit Anti-PDE8A Polyclonal Antibody – Cat# MBS617631

PDE8A (10ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human prostate, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.

Phosphodiesterase 8a (PDE8A) Antibody – Rabbit Polyclonal

Name: PDE8A Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS617631
Price: 835 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS617631

MBS617631 is an antibody targeting PDE8A. Also known as Phosphodiesterase 8A (PDE8A, EC 3.1.4.17, FLJ16150, HST19550). Reactive in Human. Host: Rabbit. More details

$835 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Phosphodiesterase 8A (PDE8A), Polyclonal Antibody

Full Product Name

Phosphodiesterase 8A (PDE8A, EC 3.1.4.17, FLJ16150, HST19550)

Product Gene Name

anti-PDE8A antibody

Product Synonym Names

Anti -Phosphodiesterase 8A (PDE8A, EC 3.1.4.17, FLJ16150, HST19550)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.1% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes Human Phosphodiesterase 8A (PDE8A). Species Crossreactivity: Human.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

93,304 Da

Chromosome Location

Chromosome: 15; NC_000015.9 (85525205..85682373). Location: 15q25.3

OMIM

602972

3D Structure

ModBase 3D Structure for O60658

Immunogen

Synthetic peptide, KLH-conjugated. Epitope: near N-terminus of human

Product Categories/Family for anti-PDE8A antibody

Antibodies; Abs to Enzymes; Phosphodiesterase

Applications Tested/Suitable for anti-PDE8A antibody

Immunohistochemistry (IHC)

Application Notes for anti-PDE8A antibody

Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry: 10ug/ml

Other Notes

Small volumes of anti-PDE8A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE8A. It may not necessarily be applicable to this product.

NCBI GI #

49904180

NCBI GeneID

5151

UniProt Primary Accession #

O60658

UniProt Secondary Accession #

Q6P9H3; Q969I1; Q96PC9; Q96PD0; Q96PD1; Q96T71; Q9UMB7; Q9UMC3; B3KXE6

UniProt Related Accession #

O60658; Q86XV4; Q9UMB5

NCBI Official Full Name

Phosphodiesterase 8A

NCBI Official Synonym Full Names

phosphodiesterase 8A

NCBI Official Symbol

PDE8A

NCBI Official Synonym Symbols

FLJ16150; HsT19550

UniProt Protein Name

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Protein Family

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase

UniProt Gene Name

PDE8A

UniProt Entry Name

PDE8A_HUMAN

NCBI Protein Information

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; OTTHUMP00000192898; OTTHUMP00000192899; cAMP-specific cyclic nucleotide phosphodiesterase 8A; high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

NCBI Summary for PDE8A

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt Comments for PDE8A

PDE8A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Phosphodiesterase; EC 3.1.4.53; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 15q25.3

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; signal transducer activity; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activity

Biological Process: cyclic nucleotide metabolic process; regulation of transcription, DNA-dependent; cAMP catabolic process; two-component signal transduction system (phosphorelay)

Research Articles on PDE8A

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PDE8A antibody

Products by Pathway	Pathway Diagram
G Protein Signaling Pathways antibodies	G Protein Signaling Pathways Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-PDE8A antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>6 publications with PDE8A and Neoplasms
Leukemia, Lymphocytic, Chronic, B-Cell Antibodies	>2 publications with PDE8A and Leukemia, Lymphocytic, Chronic, B-Cell
Inflammation Antibodies	>2 publications with PDE8A and Inflammation
Diabetes Mellitus, Type 2 Antibodies	>1 publications with PDE8A and Diabetes Mellitus, Type 2
Neurodegenerative Diseases Antibodies	>1 publications with PDE8A and Neurodegenerative Diseases
Thyroid Diseases Antibodies	>1 publications with PDE8A and Thyroid Diseases
Gonadal Disorders Antibodies	>1 publications with PDE8A and Gonadal Disorders

Organs/Tissues associated with anti-PDE8A antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with PDE8A and Blood
Testis Antibodies	>5 publications with PDE8A and Testis
Brain Antibodies	>4 publications with PDE8A and Brain
Ovary Antibodies	>3 publications with PDE8A and Ovary
Muscle Antibodies	>3 publications with PDE8A and Muscle
Bone Antibodies	>2 publications with PDE8A and Bone
Pancreas Antibodies	>2 publications with PDE8A and Pancreas
Intestine Antibodies	>2 publications with PDE8A and Intestine
Spleen Antibodies	>2 publications with PDE8A and Spleen
Adrenal Gland Antibodies	>1 publications with PDE8A and Adrenal Gland