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Plexin A3 (PLXNA3) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS617828

Plexin A3 (also known as SEX) is a 220 kD member of the Plexin A subfamily of semaphorin receptors. Mature mouse Plexin A3 is predicted to be an 1853 amino acid (aa) type I transmembrane glycoprotein that contains a 1202 aa extracellular domain (ECD) and a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Plexin A3 (PLXNA3), Polyclonal Antibody
Full Product Name
Plexin A3 (SEX)
Product Gene Name
anti-PLXNA3 antibody
Product Synonym Names
Anti -Plexin A3 (SEX)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Mouse
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS with 5% trehalose. Reconstitute with sterile PBS, 40-50% glycerol. If 0.5ml is used, the concentration will be 0.2mg/ml.
Purity/Purification
Affinity Purified
Purified by mouse Plexin A3 affinity chromatography.
Specificity
Selected for its ability to recognize mouse Plexin A3 in the applications listed. In direct ELISAs and Western Blots, this antibody shows less than 5% crossreactivity with rmPlexin A1, rmPlexin A2, rhPlexin B1, rhPlexin C1, and rhPlexin D1.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile PBS with 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
207,703 Da
Chromosome Location
Chromosome: X; NC_000023.10 (153686623..153701985). Location: Xq28
OMIM
300022
3D Structure
ModBase 3D Structure for P51805
Immunogen
E. coli-derived recombinant mouse Plexin A3 (aa34-150)

Product Categories/Family for anti-PLXNA3 antibody

Antibodies; Abs to Plexin; Semaphorin
Applications Tested/Suitable for anti-PLXNA3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PLXNA3 antibody
Western Blot: This antibody can be used at 0.1-0.2ug/ml with the appropriate secondary reagents to detect mouse Plexin A3. The detection limit for rmPlexin A3 is approximately 2 ng/lane under non-reducing and reducing conditions., Immunohistochemistry: This antibody has been used at a concentration of 10ug/ml to detect Plexin A3 in cryosections of E13 mouse embryos. Tissue was fixed overnight in 4%PFA+14%picric acid in PBS at 4 degree C. Sections were blocked with 10% donkey serum and 0.1% Triton in 1% BSA in PBS for 45 minutes at room temperature. After blocking, sections were incubated with primary antibody for 3 hours at room temperature followed by NorthernLightsTM 557 donkey anti-goat lgG at room temperature for 1 hour. Between each step, sections were washed with 0.1% BSA in PBS., Direct ELISA: This antibody can be used at 0.5-1.0ug/ml with the appropriate secondary reagents to detect mouse Plexin A3. The detection limit for rmPlexin A3 is approximately 1.0 ng/well., Optimal dilutions should be determined by each laboratory for each application.

Other Notes

Small volumes of anti-PLXNA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLXNA3 purchase

MBS617828 is an antibody targeting PLXNA3. Also known as Plexin A3 (SEX). Reactive in Mouse. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for PLXNA3. It may not necessarily be applicable to this product.

NCBI GI #
57284197
NCBI GeneID
55558
UniProt Primary Accession #
P51805
UniProt Secondary Accession #
Q5HY36
UniProt Related Accession #
P51805
NCBI Official Full Name
plexin A3
NCBI Official Synonym Full Names
plexin A3
NCBI Official Symbol
PLXNA3
NCBI Official Synonym Symbols
6.3; SEX; PLXN3; PLXN4; XAP-6; HSSEXGENE; PLEXIN-A3
UniProt Protein Name
Plexin-A3
UniProt Synonym Protein Names
Plexin-4; Semaphorin receptor SEX
Protein Family
Plexin
UniProt Gene Name
PLXNA3
UniProt Synonym Gene Names
PLXN4; SEX
UniProt Entry Name
PLXA3_HUMAN
NCBI Protein Information
plexin-A3; plexin-4; OTTHUMP00000032114; semaphorin receptor SEX; Sex chromosome X transmembrane protein of HGF receptor family 3

NCBI Summary for PLXNA3

The protein encoded by this gene is a member of the plexin class of proteins. The encoded protein is a transmembrane protein that is exposed on the cell surface. This gene is thought to be involved in epithelial and neural tissue development. [provided by RefSeq]

UniProt Comments for PLXNA3

PLXNA3: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: membrane; integral to membrane; plasma membrane; intracellular

Molecular Function: protein binding; transmembrane receptor activity; semaphorin receptor activity

Biological Process: facial nerve structural organization; axon guidance; trigeminal nerve structural organization; branchiomotor neuron axon guidance; multicellular organismal development; hippocampus development; negative chemotaxis; positive regulation of cytoskeleton organization and biogenesis; pyramidal neuron development; negative regulation of axon extension involved in axon guidance
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Research Articles on PLXNA3

1. Data show that the expression of Sema3A receptors (neuropilin-1 (NRP-1), NRP-2, plexin A1, plexin A2, and plexin A3) significantly increased during M-CSF-mediated differentiation of monocytes into macrophages.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PLXNA3 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway antibodies  SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway Diagram
 Sema3A PAK Dependent Axon Repulsion Pathway antibodies  Sema3A PAK Dependent Axon Repulsion Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-PLXNA3 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >3 publications with PLXNA3 and Death
 Adenocarcinoma Antibodies  >1 publications with PLXNA3 and Adenocarcinoma
 Pancreatic Neoplasms Antibodies  >1 publications with PLXNA3 and Pancreatic Neoplasms
 Fibrosis Antibodies  >1 publications with PLXNA3 and Fibrosis
 Abdominal Neoplasms Antibodies  >1 publications with PLXNA3 and Abdominal Neoplasms

Organs/Tissues associated with anti-PLXNA3 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >30 publications with PLXNA3 and Nerve
 Brain Antibodies  >16 publications with PLXNA3 and Brain
 Embryonic Tissue Antibodies  >10 publications with PLXNA3 and Embryonic Tissue
 Blood Antibodies  >4 publications with PLXNA3 and Blood
 Bone Antibodies  >3 publications with PLXNA3 and Bone
 Kidney Antibodies  >3 publications with PLXNA3 and Kidney
 Bone Marrow Antibodies  >3 publications with PLXNA3 and Bone Marrow
 Vascular Antibodies  >2 publications with PLXNA3 and Vascular
 Lung Antibodies  >2 publications with PLXNA3 and Lung
 Testis Antibodies  >1 publications with PLXNA3 and Testis
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