Angiotensin Factor-1 Receptor (AGTR2) Antibody – Sheep Polyclonal

AT2: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Cellular Component: membrane; perinuclear region of cytoplasm; plasma membrane; integral to membrane; intracellular

Molecular Function: G-protein coupled receptor activity; signal transducer activity; angiotensin type II receptor activity; peptide hormone binding; transcription factor binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; regulation of transcription factor import into nucleus; negative regulation of icosanoid secretion; negative regulation of heart rate; negative regulation of nerve growth factor receptor signaling pathway; regulation of vasodilation; positive regulation of transcription, DNA-dependent; renin-angiotensin regulation of aldosterone production; dopamine biosynthetic process; signal transduction; positive regulation of vasodilation; angiotensin mediated vasodilation involved in regulation of systemic arterial blood pressure; regulation of apoptosis; cerebellar cortex development; cell surface receptor linked signal transduction; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; positive regulation of cell proliferation; negative regulation of neuron apoptosis; inflammatory response; cellular sodium ion homeostasis; positive regulation of nitric-oxide synthase activity; brain renin-angiotensin system; G-protein coupled receptor protein signaling pathway; negative regulation of fibroblast proliferation; G-protein signaling, coupled to cGMP nucleotide second messenger; positive regulation of cytokine secretion